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Reviewed, UniProtKB/Swiss-Prot Q3MGA0 (DDL_ANAVT)

Last modified February 9, 2010. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    D-alanine--D-alanine ligase
    EC=6.3.2.4
Alternative name(s):
    D-alanylalanine synthetase
    D-Ala-D-Ala ligase
Gene names
Name: ddl
Ordered Locus Names: Ava_0360
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

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Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP MF_00047

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00047

Subcellular location

Cytoplasm By similarity HAMAP MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367D-alanine--D-alanine ligase HAMAP MF_00047
PRO_1000030423

Regions

Domain148 – 357210ATP-grasp
Nucleotide binding184 – 23956ATP By similarity

Sites

Metal binding3101Magnesium or manganese 1 By similarity
Metal binding3241Magnesium or manganese 1 By similarity
Metal binding3241Magnesium or manganese 2 By similarity
Metal binding3261Magnesium or manganese 2 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3MGA0-1 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: C7E4A822197A0DC5

FASTA36739,782
        10         20         30         40         50         60 
MSKLRVGLLF GGRSGEHEVS ISSARAIASA LSAGENASKY EILPFYIHKD GRWLAGEAPQ 

        70         80         90        100        110        120 
QVLKSGAPLL ESSNSSPADN NLVNSQQQTL ERWQSPSQVA EVDVWFPILH GPNGEDGTIQ 

       130        140        150        160        170        180 
GLLTLMQTPF VGSGVLGSAL GMDKIAMKMA FEQAGLPQVK YKAVTRAQIW SNPCVFPKLC 

       190        200        210        220        230        240 
DEIEASLGYP CFVKPANLGS SVGISKVRSR QELEDALDNA ANYDRRIIVE AGVVAREVEC 

       250        260        270        280        290        300 
AVLGNDQPQA STVGEITFNS DFYDYETKYT AGKADLLIPA VIPDEISRQI QDMALQAFAA 

       310        320        330        340        350        360 
VDAAGLARVD FFYVEATGEV LINEINTLPG FTATSMYPQL WAYSGIPFPE LVDKLVQLAI 


ERHNPSH

« Hide

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References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000117 Genomic DNA. Translation: ABA19986.1.
RefSeqYP_320881.1.

3D structure databases

SMRQ3MGA0. Positions 1-360.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3MGA0.

Genome annotation databases

GeneID3682734.
GenomeReviewsGene locus Ava_0360 in contig CP000117_GR.
KEGGava:Ava_0360.
NMPDRfig|240292.3.peg.961.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHBG427092.
OMAFTDISMY.
PhylomeDBQ3MGA0.

Enzyme and pathway databases

BioCycAVAR240292:AVA_0360-MONOMER.

Family and domain databases

HAMAPMF_00047. Dala_Dala_lig.
[Tree]
InterProIPR011761. ATP-grasp.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR013817. Pre-ATP_grasp.
IPR016185. PreATP-grasp-like.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDDL_ANAVT
AccessionPrimary (citable) accession number: Q3MGA0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents