Q3MG30 (ARGC_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Ava_0430

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm Probable HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_1000065137
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3MG30 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: A01B081ADD12A23C	FASTA	322	34,832
	10 20 30 40 50 60 MNKPKIFIDG EAGTTGLQIY SRLNERDDIE LVSIAASKRK DADERAKLLN SVDVAILCLP 70 80 90 100 110 120 DDAAREAVSL VHSSQVKILD ASTAYRTAQG WVYGFPELNP GQREKIANAQ FVSNPGCYPT 130 140 150 160 170 180 GFLACVRPLI AQGILPSSFP ITINAVSGYS GGGKSLIQKY DSFHEQQKGA TSDYPFGIYG 190 200 210 220 230 240 LQFGHKHVKE MHQHSGLASP PLFIPAVGDF EQGMLVQIPL PLWTLDNPPS GEEIHQAIAQ 250 260 270 280 290 300 YYQGEKFVQV ASFKDPSLLR DGTFLDATAV NGTNIVQVFV FANDNTKEAL LVARLDNLGK 310 320 GASGAAVQNL NIMLGLPEEL GL

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000117 Genomic DNA. Translation: ABA20056.1.
RefSeq	YP_320951.1. NC_007413.1.
3D structure databases
HSSP	HSSP built from PDB template 1VKN based on UniProtKB Q9X2A2.
ProteinModelPortal	Q3MG30.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MG30.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3682591.
GenomeReviews	Gene locus Ava_0430 in contig CP000117_GR.
KEGG	ava:Ava_0430.
NMPDR	fig|240292.3.peg.1312.
PATRIC	35421201. VBIAnaVar43351_1173.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	PIFVPSV.
PhylomeDB	Q3MG30.
ProtClustDB	PRK11863.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_0430-MONOMER.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR023013. AGPR_AS. IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_ANAVT

Accession

Primary (citable) accession number: Q3MG30

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 25, 2005
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program