ID   DAPB_ANAVT              Reviewed;         278 AA.
AC   Q3MFY8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Dihydrodipicolinate reductase;
DE            Short=DHPR;
DE            EC=1.3.1.26;
GN   Name=dapB; OrderedLocusNames=Ava_0474;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) =
CC       2,3-dihydrodipicolinate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the dihydrodipicolinate reductase family.
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DR   EMBL; CP000117; ABA20098.1; -; Genomic_DNA.
DR   RefSeq; YP_320993.1; -.
DR   GeneID; 3682440; -.
DR   GenomeReviews; CP000117_GR; Ava_0474.
DR   KEGG; ava:Ava_0474; -.
DR   NMPDR; fig|240292.3.peg.1613; -.
DR   HOGENOM; Q3MFY8; -.
DR   OMA; Q3MFY8; IRGGSIV.
DR   BioCyc; AVAR240292:AVA_0474-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0008839; F:dihydrodipicolinate reductase activity; IEA:HAMAP.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00102; -; 1.
DR   InterPro; IPR000846; DapB.
DR   InterPro; IPR011770; DapB_bac/pln.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR20836; DapB_bac/pln; 1.
DR   Pfam; PF05173; DapB_C; 1.
DR   Pfam; PF01113; DapB_N; 1.
DR   ProDom; PD004105; DapB; 1.
DR   TIGRFAMs; TIGR00036; dapB; 1.
DR   PROSITE; PS01298; DAPB; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Diaminopimelate biosynthesis; Lysine biosynthesis; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    278       Dihydrodipicolinate reductase.
FT                                /FTId=PRO_1000057677.
SQ   SEQUENCE   278 AA;  29464 MW;  F02D1FF0D93EBD6B CRC64;
     MTNQAPIPVI VNGAAGKMGR EVVKAIAQAP DLNLLGAIDS SPEHQGKDAG ELAGLSEPLE
     VPITNQLEPM LGYVAGERQG PPGVIVDFTH PDSVYDNVRS AIAYGIRPVV GTTGLSPAQI
     QNLADFAEKA STGCLIIPNF SIGMVLLQQA AVTASQYFDH VEIIELHHNQ KADAPSGTAI
     QTAELLAELG KTFNSAIVEE TEKIPGARGS LAGEGIRIHS VRLPGLIAHQ EVIFGAPGQI
     YTLRHDTSDR ACYMPGVLLA IRKVLQLKSL VYGLEKIL
//