Q3MFQ8 (ARGB_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Ava_0554

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000264680
Regions
	Region	73 – 74	2	Substrate binding By similarity
Sites
	Binding site	95	1	Substrate By similarity
	Binding site	188	1	Substrate By similarity
	Site	38	1	Transition state stabilizer By similarity
	Site	251	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3MFQ8 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 0ABF2AD6634DA624	FASTA	297	31,530
	10 20 30 40 50 60 MMVNDIEYIR QAEATRVQVL SEALPYIQQF AGRTVVVKYG GAAMKDSHLK DQVIRDIVFL 70 80 90 100 110 120 SCVGLRPILV HGGGPEINSW LDKLGIEAQF KNGLRVTDAP TMDVVEMVLV GRVNKEIVSL 130 140 150 160 170 180 INQAGGLAVG LCGKDGNLIT ARPQGQEGIG FVGEVSNVNI KILETLASNG YIPVVSSVAA 190 200 210 220 230 240 DDSGQAYNIN ADTVAGEIAA ALGAEKLILL TDTRGILKDY KDPGTLIPKV DIREARELIN 250 260 270 280 290 GGVVSGGMIP KVTCCVRSLA QGVRAAHIID GRIPHALLLE IFTDVGIGTM ILGSQYS

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000117 Genomic DNA. Translation: ABA20178.1.
RefSeq	YP_321073.1. NC_007413.1.
3D structure databases
HSSP	HSSP built from PDB template 2BUF based on UniProtKB Q9HTN2.
ProteinModelPortal	Q3MFQ8.
SMR	Q3MFQ8. Positions 14-296.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MFQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3682326.
GenomeReviews	Gene locus Ava_0554 in contig CP000117_GR.
KEGG	ava:Ava_0554.
NMPDR	fig|240292.3.peg.2482.
PATRIC	35421492. VBIAnaVar43351_1317.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGNAMID.
PhylomeDB	Q3MFQ8.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_0554-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ANAVT

Accession

Primary (citable) accession number: Q3MFQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 25, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program