Reviewed, UniProtKB/Swiss-Prot Q3MFM3 (AROC_ANAVT)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	Ava_0589

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Chorismate synthase HAMAP MF_00300		PRO_0000256270

Sequences

	Sequence		Length	Mass (Da)
	Q3MFM3-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 4DD32588F01C22FC	FASTA	362	39,339
	10 20 30 40 50 60 MGNTFGHLFR ITTFGESHGG GVGVVIDGCP PLLEISPEEI QLELDRRRPG QSKITTPRKE 70 80 90 100 110 120 ADTCEILSGV YEGKTLGTPI SILVRNKDTR PQDYDEMAQK YRPSHADATY DAKYGIRNWQ 130 140 150 160 170 180 GGGRSSARET IGRVAAGAIA KKILRQVANV EVIGYVKRIK DLEGVVDPNT VTLDQVESNI 190 200 210 220 230 240 VRCPDGELAD RMIELIEQTG RQGDSIGGVV ECVARNVPKG LGEPVFDKLE ADIAKAVMSL 250 260 270 280 290 300 PASKGFEIGS GFAGTLLTGF EHNDEYYIDE NGEIRTVTNR SGGIQGGIAN GENIILRVAF 310 320 330 340 350 360 KPTATIRKEQ KTVTREGEET LLAAKGRHDP CVLPRAVPMV EAMVALVLCD HLLRHHGQCK VL

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA20213.1.
RefSeq	YP_321108.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MFM3.
Genome annotation databases
GeneID	3678619.
GenomeReviews	Gene locus Ava_0589 in contig CP000117_GR.
KEGG	ava:Ava_0589.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3MFM3.
OMA	SRFTTQR.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_0589-MON.
Family and domain databases
HAMAP	MF_00300. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
ProDom	PD002941. Chorismate_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ANAVT

Accession

Primary (citable) accession number: Q3MFM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 25, 2005
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)