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Q3MFH9 (UPPP_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Ava_0633
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000250223

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane296 – 31621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q3MFH9 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: DA9BE946B4C997E7

FASTA32033,975
        10         20         30         40         50         60 
MTLFKRQWFV LVSAVSAALS VVLFPLEVFS ASPNSVGGGV QQMNILQAIV LGFVQGMTEF 

        70         80         90        100        110        120 
LPISSTAHLK VVPVALGWGD PGVAFTAIIQ LGSIAAVLWY FWGDLTRIIK GATRAIALKD 

       130        140        150        160        170        180 
YADYDLRLSL GIILGTIPIV FFGLLIKKLI PDFDSSPIRS LGAIAVASIV MSLLLGVGEK 

       190        200        210        220        230        240 
LGKRERDFEH LTMQDGLLMG LAQALALIPG VSRSGSTLTS GLFMGLQRET AARFSFLLGI 

       250        260        270        280        290        300 
PAITLAGLVE LKDVFAEGIA DGAALPLIVG VISAAIFSYM AIAGLLSFLK TQSTWVFIWY 

       310        320 
RLVFGIAILG AISAGILQNS 

« Hide

References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000117 Genomic DNA. Translation: ABA20257.1.
RefSeqYP_321152.1. NC_007413.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING240292.Ava_0633.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA20257; ABA20257; Ava_0633.
GeneID3678662.
KEGGava:Ava_0633.
PATRIC35421658. VBIAnaVar43351_1400.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMALVGCFQC.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycAVAR240292:GCY3-636-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_ANAVT
AccessionPrimary (citable) accession number: Q3MFH9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 25, 2005
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families