ID   Q3MFD3_TRIV2            Unreviewed;       576 AA.
AC   Q3MFD3;
DT   25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase {ECO:0000313|EMBL:ABA20303.1};
GN   OrderedLocusNames=Ava_0679 {ECO:0000313|EMBL:ABA20303.1};
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
OC   Trichormus.
OX   NCBI_TaxID=240292 {ECO:0000313|EMBL:ABA20303.1, ECO:0000313|Proteomes:UP000002533};
RN   [1] {ECO:0000313|Proteomes:UP000002533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937 {ECO:0000313|Proteomes:UP000002533};
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
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DR   EMBL; CP000117; ABA20303.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3MFD3; -.
DR   STRING; 240292.Ava_0679; -.
DR   KEGG; ava:Ava_0679; -.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_70_50_3; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        27..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        60..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          164..298
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          307..561
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   576 AA;  64577 MW;  6BEC484AA1CB2131 CRC64;
     MQLNQKLYLY STLDNFRLLN KNYTAKIMLV AFLGTHIPLL TLLFSFVISN SYSWEMTIRV
     LVIALFATLI GTVVTLYALH HLLIPVNLTS ATLRDYLNNK TLPNLPTEFV DEAGTLMADT
     SQTLHKLDEL IDYISNYDKL TGLPNRELLR ERVNQALSQQ YSQKMVAVMV LGIDDFTGIS
     HALEHEQSNL LLRAVGQRLT SCLAQKDILA HLSGDEFAIA RVEIPSIESI VKLSQLLLSA
     LNKPFTIKGD QIHITASIGI TINQPDNLHD VDQLLQQAHV ALYQAKQQGR SQHQFYSPEI
     NAQLQERLAL ENELHGALQR NEIVVYYQPI IDLQTQQITA VEALVRWQHP TRGLVSPAKF
     IPIAEANGLI VEIGEWVLRT ACLQNRAWQL AGLPPIRMSV NLSARQFEES NLVELVGEII
     QESGLHPSYL ELEVTESSLM ADIQRSVTIL KQLRELGVWL ALDDFGTGYS SLNYLKRFPV
     NMLKIDRSFV QDVCSNPDSA AVTNAIIALA KSLQLKITAE GIETQQQLSY LQKRGCQEGQ
     GYYFGIPAPA NEITEILQPE EAKEAMLYDR PGVIAV
//