UniProtKB - Q3MF40 (PGK_ANAVT)
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Protein
Phosphoglycerate kinase
Gene
pgk
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Functioni
Catalytic activityi
ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation
: glycolysis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- Glyceraldehyde-3-phosphate dehydrogenase 3 (gap3), Glyceraldehyde-3-phosphate dehydrogenase 1 (gap1)
- Phosphoglycerate kinase (pgk)
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
- Enolase (eno)
- Pyruvate kinase (Ava_0494), Pyruvate kinase (Ava_1694)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 40 | SubstrateUniRule annotation | 1 | |
Binding sitei | 121 | SubstrateUniRule annotation | 1 | |
Binding sitei | 154 | SubstrateUniRule annotation | 1 | |
Binding sitei | 205 | ATPUniRule annotation | 1 | |
Binding sitei | 296 | ATP; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 327 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 356 – 359 | ATPUniRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- phosphoglycerate kinase activity Source: UniProtKB-EC
GO - Biological processi
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Glycolysis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | AVAR240292:G7WH-7689-MONOMER. |
UniPathwayi | UPA00109; UER00185. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pgkUniRule annotation Ordered Locus Names:Ava_0772 |
Organismi | Anabaena variabilis (strain ATCC 29413 / PCC 7937) |
Taxonomic identifieri | 240292 [NCBI] |
Taxonomic lineagei | Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Trichormus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000057959 | 1 – 400 | Phosphoglycerate kinaseAdd BLAST | 400 |
Interactioni
Subunit structurei
Monomer.UniRule annotation
Protein-protein interaction databases
STRINGi | 240292.Ava_0772. |
Structurei
3D structure databases
ProteinModelPortali | Q3MF40. |
SMRi | Q3MF40. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 26 | Substrate bindingUniRule annotation | 3 | |
Regioni | 63 – 66 | Substrate bindingUniRule annotation | 4 |
Sequence similaritiesi
Belongs to the phosphoglycerate kinase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105BZA. Bacteria. COG0126. LUCA. |
HOGENOMi | HOG000227108. |
KOi | K00927. |
OMAi | DMIFDIG. |
OrthoDBi | POG091H00YN. |
Family and domain databases
CDDi | cd00318. Phosphoglycerate_kinase. 1 hit. |
Gene3Di | 3.40.50.1260. 3 hits. |
HAMAPi | MF_00145. Phosphoglyc_kinase. 1 hit. |
InterProi | View protein in InterPro IPR001576. Phosphoglycerate_kinase. IPR015824. Phosphoglycerate_kinase_N. IPR036043. Phosphoglycerate_kinase_sf. |
PANTHERi | PTHR11406. PTHR11406. 1 hit. |
Pfami | View protein in Pfam PF00162. PGK. 1 hit. |
PIRSFi | PIRSF000724. Pgk. 1 hit. |
PRINTSi | PR00477. PHGLYCKINASE. |
SUPFAMi | SSF53748. SSF53748. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q3MF40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKKTVASLS AADISGKRAL VRVDFNVPLD DQGNITDDTR IRAALPTIQD
60 70 80 90 100
LTQKGAKVIL ASHFGRPKGV DEKLRLTPVA KRLSELLGQE VVKTDDSIGD
110 120 130 140 150
EVAAKVAALQ NGQVLLLENV RFYKEEEKND PEFAKKLAAN ADFYVNDAFG
160 170 180 190 200
TAHRAHASTE GVTKFLSPSV AGYLVEKELQ YLQSAIENPQ RPLAAIIGGS
210 220 230 240 250
KVSSKIGVIE TLLEKCDKLI IGGGMIFTFY KARGLNVGKS LVEEDKLELA
260 270 280 290 300
KSLEAKAKER GVSLLLPTDV VLADNFAPDA NSQTVSIDNI PDGWMGLDIG
310 320 330 340 350
PDSVKVFQEA LADTKTVIWN GPMGVFEFDK FAAGTEAIAH TLAEIGKTGT
360 370 380 390 400
TTIIGGGDSV AAVEKVGLAD QMSHISTGGG ASLELLEGKV LPGIAALDEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000117 Genomic DNA. Translation: ABA20396.1. |
Genome annotation databases
EnsemblBacteriai | ABA20396; ABA20396; Ava_0772. |
KEGGi | ava:Ava_0772. |
Similar proteinsi
Entry informationi
Entry namei | PGK_ANAVT | |
Accessioni | Q3MF40Primary (citable) accession number: Q3MF40 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | October 25, 2005 | |
Last modified: | February 28, 2018 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |