pgk

Functionⁱ

Catalytic activityⁱ

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	40	SubstrateUniRule annotation	1
Binding siteⁱ	121	SubstrateUniRule annotation	1
Binding siteⁱ	154	SubstrateUniRule annotation	1
Binding siteⁱ	205	ATPUniRule annotation	1
Binding siteⁱ	296	ATP; via carbonyl oxygenUniRule annotation	1
Binding siteⁱ	327	ATPUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	356 – 359	ATPUniRule annotation		4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
phosphoglycerate kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycolytic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Glycolysis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	AVAR240292:G7WH-7689-MONOMER.
UniPathwayⁱ	UPA00109; UER00185.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesⁱ	Name:pgkUniRule annotation Ordered Locus Names:Ava_0772
Organismⁱ	Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifierⁱ	240292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Cyanobacteria › Nostocales › Nostocaceae › Trichormus › Anabaena variabilis
Proteomesⁱ	UP000002533 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00145

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000057959	1 – 400	Phosphoglycerate kinaseAdd BLAST		400

Interactionⁱ

Subunit structureⁱ

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	240292.Ava_0772.

STRINGⁱ

240292.Ava_0772.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3MF40.
SMRⁱ	Q3MF40.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	24 – 26	Substrate bindingUniRule annotation		3
Regionⁱ	63 – 66	Substrate bindingUniRule annotation		4

Sequence similaritiesⁱ

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105BZA. Bacteria. COG0126. LUCA.
HOGENOMⁱ	HOG000227108.
KEGG Orthology (KO) More...KOⁱ	K00927.
OMAⁱ	DMIFDIG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00YN.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Dⁱ	3.40.50.1260. 3 hits.
HAMAPⁱ	MF_00145. Phosphoglyc_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR001576. Phosphoglycerate_kinase. IPR015824. Phosphoglycerate_kinase_N. IPR036043. Phosphoglycerate_kinase_sf.
PANTHERⁱ	PTHR11406. PTHR11406. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00162. PGK. 1 hit.
PIRSFⁱ	PIRSF000724. Pgk. 1 hit.
PRINTSⁱ	PR00477. PHGLYCKINASE.
SUPFAMⁱ	SSF53748. SSF53748. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3MF40-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKKTVASLS AADISGKRAL VRVDFNVPLD DQGNITDDTR IRAALPTIQD 
        60         70         80         90        100
LTQKGAKVIL ASHFGRPKGV DEKLRLTPVA KRLSELLGQE VVKTDDSIGD 
       110        120        130        140        150
EVAAKVAALQ NGQVLLLENV RFYKEEEKND PEFAKKLAAN ADFYVNDAFG 
       160        170        180        190        200
TAHRAHASTE GVTKFLSPSV AGYLVEKELQ YLQSAIENPQ RPLAAIIGGS 
       210        220        230        240        250
KVSSKIGVIE TLLEKCDKLI IGGGMIFTFY KARGLNVGKS LVEEDKLELA 
       260        270        280        290        300
KSLEAKAKER GVSLLLPTDV VLADNFAPDA NSQTVSIDNI PDGWMGLDIG 
       310        320        330        340        350
PDSVKVFQEA LADTKTVIWN GPMGVFEFDK FAAGTEAIAH TLAEIGKTGT 
       360        370        380        390        400
TTIIGGGDSV AAVEKVGLAD QMSHISTGGG ASLELLEGKV LPGIAALDEA

Length:400

Mass (Da):42,441

Last modified:October 25, 2005 - v1

Checksum:ⁱ3B7DF324A5A21178

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000117 Genomic DNA. Translation: ABA20396.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP000117 Genomic DNA. Translation: ABA20396.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABA20396; ABA20396; Ava_0772.
KEGGⁱ	ava:Ava_0772.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q3MF40	A0A1W5CG90	Anabaena sp. 39858	400	UniRef100_Q3MF40	Cluster: Phosphoglycerate kinase	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q3MF40	Q8YPR1 A0A1Z4KLB1 A0A2H6LBA0 A0A1W5CG90 B2ITU1 A0A1Z4GLV0 A0A0D6L107 A0A1Z4MDF0 A0A1Z4U6Q9 A0A1Z4N662 +64	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) Trichormus variabilis NIES-23 Nostoc cycadae WK-1 Anabaena sp. 39858 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) Anabaenopsis circularis NIES-21 Tolypothrix sp. PCC 7601 Fremyella diplosiphon NIES-3275 Aulosira laxa NIES-50 Tolypothrix tenuis PCC 7101 And more	400	UniRef90_Q8YPR1	Cluster: Phosphoglycerate kinase	75

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q3MF40	Q8YPR1 A0A1Z4KLB1 A0A2H6LBA0 UPI0002D98C33 UPI00047EE675 A0A1Y0RL41 K9ZP72 K9QXW2 UPI00083277E6 A0A1W5CG90 +587	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) Trichormus variabilis NIES-23 Nostoc cycadae WK-1 Fischerella muscicola Fischerella sp. PCC 9605 Nostocales cyanobacterium HT-58-2 Anabaena cylindrica (strain ATCC 27899 / PCC 7122) Nostoc sp. (strain ATCC 29411 / PCC 7524) Anabaena Anabaena sp. 39858 And more	400	UniRef50_Q8YPR1	Cluster: Phosphoglycerate kinase	598

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000117 Genomic DNA. Translation: ABA20396.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP000117 Genomic DNA. Translation: ABA20396.1.

3D structure databases

ProteinModelPortalⁱ	Q3MF40.
SMRⁱ	Q3MF40.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	240292.Ava_0772.

STRINGⁱ

240292.Ava_0772.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABA20396; ABA20396; Ava_0772.
KEGGⁱ	ava:Ava_0772.

Phylogenomic databases

eggNOGⁱ	ENOG4105BZA. Bacteria. COG0126. LUCA.
HOGENOMⁱ	HOG000227108.
KEGG Orthology (KO) More...KOⁱ	K00927.
OMAⁱ	DMIFDIG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00YN.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00185.
BioCycⁱ	AVAR240292:G7WH-7689-MONOMER.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Dⁱ	3.40.50.1260. 3 hits.
HAMAPⁱ	MF_00145. Phosphoglyc_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR001576. Phosphoglycerate_kinase. IPR015824. Phosphoglycerate_kinase_N. IPR036043. Phosphoglycerate_kinase_sf.
PANTHERⁱ	PTHR11406. PTHR11406. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00162. PGK. 1 hit.
PIRSFⁱ	PIRSF000724. Pgk. 1 hit.
PRINTSⁱ	PR00477. PHGLYCKINASE.
SUPFAMⁱ	SSF53748. SSF53748. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PGK_ANAVT
Accessionⁱ	Q3MF40Primary (citable) accession number: Q3MF40
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	October 25, 2005
	Last modified:	February 28, 2018
	This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3MF40 (PGK_ANAVT)

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Phosphoglycerate kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ