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Protein

Endonuclease V

Gene

nfi

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441MagnesiumUniRule annotation
Metal bindingi112 – 1121MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-824-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:Ava_0819
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
Proteomesi
  • UP000002533 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Endonuclease VPRO_1000046991Add
BLAST

Interactioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei82 – 821Interaction with target DNAUniRule annotation

Protein-protein interaction databases

STRINGi240292.Ava_0819.

Structurei

3D structure databases

ProteinModelPortaliQ3MEZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105Y7X. Bacteria.
COG1515. LUCA.
HOGENOMiHOG000229135.
KOiK05982.
OMAiREYPALM.
OrthoDBiEOG6C0163.

Family and domain databases

HAMAPiMF_00801. Endonuclease_5.
InterProiIPR007581. Endonuclease-V.
[Graphical view]
PfamiPF04493. Endonuclease_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MEZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIYQPHPWP LTVEEAITIQ EELRHQVITQ DQFTQPVQYV AGVDMGFEAD
60 70 80 90 100
GTISRAAVAV LSFPDLQVVE TSLAYRPTSF PYIPGFLSFR EIPAVLDALE
110 120 130 140 150
KIQTKPDIIL CDGQGIAHPR RLGIASHLGV LLNIPTIGVA KSLLIGRHEE
160 170 180 190 200
LADTKGSWQP LIHRGEIIGA VLRTRVGVKP VYVSSGHKIS LPTAIDYVLR
210 220
CTPKYRLPET TRVADKLASN R
Length:221
Mass (Da):24,435
Last modified:October 25, 2005 - v1
Checksum:i919E0B321D580D00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA20443.1.

Genome annotation databases

EnsemblBacteriaiABA20443; ABA20443; Ava_0819.
KEGGiava:Ava_0819.
PATRICi35422054. VBIAnaVar43351_1597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA20443.1.

3D structure databases

ProteinModelPortaliQ3MEZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi240292.Ava_0819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA20443; ABA20443; Ava_0819.
KEGGiava:Ava_0819.
PATRICi35422054. VBIAnaVar43351_1597.

Phylogenomic databases

eggNOGiENOG4105Y7X. Bacteria.
COG1515. LUCA.
HOGENOMiHOG000229135.
KOiK05982.
OMAiREYPALM.
OrthoDBiEOG6C0163.

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-824-MONOMER.

Family and domain databases

HAMAPiMF_00801. Endonuclease_5.
InterProiIPR007581. Endonuclease-V.
[Graphical view]
PfamiPF04493. Endonuclease_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiNFI_ANAVT
AccessioniPrimary (citable) accession number: Q3MEZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: November 11, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.