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Protein

Endonuclease V

Gene

nfi

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44MagnesiumUniRule annotation1
Metal bindingi112MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-7736-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:Ava_0819
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi
  • UP000002533 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000469911 – 221Endonuclease VAdd BLAST221

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei82Interaction with target DNAUniRule annotation1

Protein-protein interaction databases

STRINGi240292.Ava_0819

Structurei

3D structure databases

ProteinModelPortaliQ3MEZ3
SMRiQ3MEZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105Y7X Bacteria
COG1515 LUCA
HOGENOMiHOG000229135
KOiK05982
OMAiCKYRVPE
OrthoDBiPOG091H0CQB

Family and domain databases

CDDicd06559 Endonuclease_V, 1 hit
HAMAPiMF_00801 Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581 Endonuclease-V
PANTHERiPTHR28511 PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493 Endonuclease_5, 1 hit

Sequencei

Sequence statusi: Complete.

Q3MEZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIYQPHPWP LTVEEAITIQ EELRHQVITQ DQFTQPVQYV AGVDMGFEAD
60 70 80 90 100
GTISRAAVAV LSFPDLQVVE TSLAYRPTSF PYIPGFLSFR EIPAVLDALE
110 120 130 140 150
KIQTKPDIIL CDGQGIAHPR RLGIASHLGV LLNIPTIGVA KSLLIGRHEE
160 170 180 190 200
LADTKGSWQP LIHRGEIIGA VLRTRVGVKP VYVSSGHKIS LPTAIDYVLR
210 220
CTPKYRLPET TRVADKLASN R
Length:221
Mass (Da):24,435
Last modified:October 25, 2005 - v1
Checksum:i919E0B321D580D00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA Translation: ABA20443.1

Genome annotation databases

EnsemblBacteriaiABA20443; ABA20443; Ava_0819
KEGGiava:Ava_0819

Similar proteinsi

Entry informationi

Entry nameiNFI_ANAVT
AccessioniPrimary (citable) accession number: Q3MEZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health