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Protein

Diaminopimelate decarboxylase

Gene

lysA

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei275 – 2751Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei320 – 3201SubstrateUniRule annotation
Binding sitei357 – 3571SubstrateUniRule annotation
Binding sitei361 – 3611SubstrateUniRule annotation
Binding sitei389 – 3891SubstrateUniRule annotation
Binding sitei417 – 4171Pyridoxal phosphateUniRule annotation
Binding sitei417 – 4171SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-922-MONOMER.
UniPathwayiUPA00034; UER00027.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
Short name:
DAP decarboxylaseUniRule annotation
Short name:
DAPDCUniRule annotation
Gene namesi
Name:lysAUniRule annotation
Ordered Locus Names:Ava_0912Imported
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)Imported
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei98 – 981N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi240292.Ava_0912.

Structurei

3D structure databases

ProteinModelPortaliQ3MEQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni317 – 3204Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0019.
HOGENOMiHOG000045071.
KOiK01586.
OMAiHCFNVES.
OrthoDBiEOG6Z9B18.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_02120. LysA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01048. lysA. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MEQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSTHPAGVQ DAGTQYLPQR RNTNTNISPN QELLPLTAKA NSQGNLEIGG
60 70 80 90 100
CDVTTLVEQF GSPLYILDEE TLRTACQQYR DGFQKYYPGE SQVLYASKAW
110 120 130 140 150
NCLAVCAIAG SEGLGIDVVS GGELYTALAA GVSPAKIYLH GNNKSREELI
160 170 180 190 200
LAIESGVTIV ADNWYELRTL ASLTHTDQPV RIMLRLTPGI ECHTHEYIRT
210 220 230 240 250
GHLDSKFGFD PNDLAEVFEF VSQQPNLNCV GLHAHIGSQI FERQPHRDLA
260 270 280 290 300
AVMVQWLRDA NKYGLNVTEL NVGGGLGIKY VESDDPPSID EWVKAICEVV
310 320 330 340 350
QSACAAENLP LPKLLSEPGR SLIATSCVTA YTVGSSKTIP EIRTYVSIDG
360 370 380 390 400
GMSDNPRPIT YQSVYRAVIA NKLSVSHTET VTIAGKHCES GDILIKNAQL
410 420 430 440 450
PKTEPGDILV VMATGAYNYS MASNYNRLPR PAAVVVANGE ANLILQRETY
460
QDLIRQDCLP ERLK
Length:464
Mass (Da):50,665
Last modified:October 25, 2005 - v1
Checksum:i0027FB30BE673B0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA20536.1.
RefSeqiWP_011317766.1. NC_007413.1.
YP_321431.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA20536; ABA20536; Ava_0912.
KEGGiava:Ava_0912.
PATRICi35422270. VBIAnaVar43351_1700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA20536.1.
RefSeqiWP_011317766.1. NC_007413.1.
YP_321431.1. NC_007413.1.

3D structure databases

ProteinModelPortaliQ3MEQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi240292.Ava_0912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA20536; ABA20536; Ava_0912.
KEGGiava:Ava_0912.
PATRICi35422270. VBIAnaVar43351_1700.

Phylogenomic databases

eggNOGiCOG0019.
HOGENOMiHOG000045071.
KOiK01586.
OMAiHCFNVES.
OrthoDBiEOG6Z9B18.

Enzyme and pathway databases

UniPathwayiUPA00034; UER00027.
BioCyciAVAR240292:GCY3-922-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_02120. LysA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01048. lysA. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937Imported.

Entry informationi

Entry nameiQ3MEQ0_ANAVT
AccessioniPrimary (citable) accession number: Q3MEQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2005
Last sequence update: October 25, 2005
Last modified: May 27, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.