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Q3MEQ0

- Q3MEQ0_ANAVT

UniProt

Q3MEQ0 - Q3MEQ0_ANAVT

Protein

Diaminopimelate decarboxylase

Gene

lysA

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.UniRule annotation

    Catalytic activityi

    Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei275 – 2751Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei320 – 3201SubstrateUniRule annotation
    Binding sitei357 – 3571SubstrateUniRule annotation
    Binding sitei361 – 3611SubstrateUniRule annotation
    Binding sitei389 – 3891SubstrateUniRule annotation
    Binding sitei417 – 4171Pyridoxal phosphateUniRule annotation
    Binding sitei417 – 4171SubstrateUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate decarboxylase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciAVAR240292:GCY3-922-MONOMER.
    UniPathwayiUPA00034; UER00027.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
    Short name:
    DAP decarboxylaseUniRule annotation
    Short name:
    DAPDCUniRule annotation
    Gene namesi
    Name:lysAUniRule annotation
    Ordered Locus Names:Ava_0912Imported
    OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)Imported
    Taxonomic identifieri240292 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
    ProteomesiUP000002533: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei98 – 981N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi240292.Ava_0912.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MEQ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni317 – 3204Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0019.
    HOGENOMiHOG000045071.
    KOiK01586.
    OMAiHCFNVES.
    OrthoDBiEOG6Z9B18.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_02120. LysA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002986. DAP_deCOOHase_LysA.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PRINTSiPR01181. DAPDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01048. lysA. 1 hit.
    PROSITEiPS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3MEQ0-1 [UniParc]FASTAAdd to Basket

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    MVSTHPAGVQ DAGTQYLPQR RNTNTNISPN QELLPLTAKA NSQGNLEIGG    50
    CDVTTLVEQF GSPLYILDEE TLRTACQQYR DGFQKYYPGE SQVLYASKAW 100
    NCLAVCAIAG SEGLGIDVVS GGELYTALAA GVSPAKIYLH GNNKSREELI 150
    LAIESGVTIV ADNWYELRTL ASLTHTDQPV RIMLRLTPGI ECHTHEYIRT 200
    GHLDSKFGFD PNDLAEVFEF VSQQPNLNCV GLHAHIGSQI FERQPHRDLA 250
    AVMVQWLRDA NKYGLNVTEL NVGGGLGIKY VESDDPPSID EWVKAICEVV 300
    QSACAAENLP LPKLLSEPGR SLIATSCVTA YTVGSSKTIP EIRTYVSIDG 350
    GMSDNPRPIT YQSVYRAVIA NKLSVSHTET VTIAGKHCES GDILIKNAQL 400
    PKTEPGDILV VMATGAYNYS MASNYNRLPR PAAVVVANGE ANLILQRETY 450
    QDLIRQDCLP ERLK 464
    Length:464
    Mass (Da):50,665
    Last modified:October 25, 2005 - v1
    Checksum:i0027FB30BE673B0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000117 Genomic DNA. Translation: ABA20536.1.
    RefSeqiWP_011317766.1. NC_007413.1.
    YP_321431.1. NC_007413.1.

    Genome annotation databases

    EnsemblBacteriaiABA20536; ABA20536; Ava_0912.
    GeneIDi3681345.
    KEGGiava:Ava_0912.
    PATRICi35422270. VBIAnaVar43351_1700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000117 Genomic DNA. Translation: ABA20536.1 .
    RefSeqi WP_011317766.1. NC_007413.1.
    YP_321431.1. NC_007413.1.

    3D structure databases

    ProteinModelPortali Q3MEQ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 240292.Ava_0912.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA20536 ; ABA20536 ; Ava_0912 .
    GeneIDi 3681345.
    KEGGi ava:Ava_0912.
    PATRICi 35422270. VBIAnaVar43351_1700.

    Phylogenomic databases

    eggNOGi COG0019.
    HOGENOMi HOG000045071.
    KOi K01586.
    OMAi HCFNVES.
    OrthoDBi EOG6Z9B18.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00027 .
    BioCyci AVAR240292:GCY3-922-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_02120. LysA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002986. DAP_deCOOHase_LysA.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR01181. DAPDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01048. lysA. 1 hit.
    PROSITEi PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Anabaena variabilis ATCC 29413."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29413 / PCC 7937Imported.

    Entry informationi

    Entry nameiQ3MEQ0_ANAVT
    AccessioniPrimary (citable) accession number: Q3MEQ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 25, 2005
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3