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Q3MEQ0

- Q3MEQ0_ANAVT

UniProt

Q3MEQ0 - Q3MEQ0_ANAVT

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Protein

Diaminopimelate decarboxylase

Gene
lysA, Ava_0912
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine By similarity.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei275 – 2751Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei320 – 3201Substrate By similarityUniRule annotation
Binding sitei357 – 3571Substrate By similarityUniRule annotation
Binding sitei361 – 3611Substrate By similarityUniRule annotation
Binding sitei389 – 3891Substrate By similarityUniRule annotation
Binding sitei417 – 4171Pyridoxal phosphate By similarityUniRule annotation
Binding sitei417 – 4171Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. diaminopimelate decarboxylase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotations, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-922-MONOMER.
UniPathwayiUPA00034; UER00027.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
Short name:
DAP decarboxylaseUniRule annotation
Short name:
DAPDCUniRule annotation
Gene namesi
Name:lysAUniRule annotation
Ordered Locus Names:Ava_0912Imported
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)Imported
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei98 – 981N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi240292.Ava_0912.

Structurei

3D structure databases

ProteinModelPortaliQ3MEQ0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni317 – 3204Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0019.
HOGENOMiHOG000045071.
KOiK01586.
OMAiHCFNVES.
OrthoDBiEOG6Z9B18.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_02120. LysA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01048. lysA. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MEQ0-1 [UniParc]FASTAAdd to Basket

« Hide

MVSTHPAGVQ DAGTQYLPQR RNTNTNISPN QELLPLTAKA NSQGNLEIGG    50
CDVTTLVEQF GSPLYILDEE TLRTACQQYR DGFQKYYPGE SQVLYASKAW 100
NCLAVCAIAG SEGLGIDVVS GGELYTALAA GVSPAKIYLH GNNKSREELI 150
LAIESGVTIV ADNWYELRTL ASLTHTDQPV RIMLRLTPGI ECHTHEYIRT 200
GHLDSKFGFD PNDLAEVFEF VSQQPNLNCV GLHAHIGSQI FERQPHRDLA 250
AVMVQWLRDA NKYGLNVTEL NVGGGLGIKY VESDDPPSID EWVKAICEVV 300
QSACAAENLP LPKLLSEPGR SLIATSCVTA YTVGSSKTIP EIRTYVSIDG 350
GMSDNPRPIT YQSVYRAVIA NKLSVSHTET VTIAGKHCES GDILIKNAQL 400
PKTEPGDILV VMATGAYNYS MASNYNRLPR PAAVVVANGE ANLILQRETY 450
QDLIRQDCLP ERLK 464
Length:464
Mass (Da):50,665
Last modified:October 25, 2005 - v1
Checksum:i0027FB30BE673B0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA20536.1.
RefSeqiWP_011317766.1. NC_007413.1.
YP_321431.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA20536; ABA20536; Ava_0912.
GeneIDi3681345.
KEGGiava:Ava_0912.
PATRICi35422270. VBIAnaVar43351_1700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA20536.1 .
RefSeqi WP_011317766.1. NC_007413.1.
YP_321431.1. NC_007413.1.

3D structure databases

ProteinModelPortali Q3MEQ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240292.Ava_0912.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA20536 ; ABA20536 ; Ava_0912 .
GeneIDi 3681345.
KEGGi ava:Ava_0912.
PATRICi 35422270. VBIAnaVar43351_1700.

Phylogenomic databases

eggNOGi COG0019.
HOGENOMi HOG000045071.
KOi K01586.
OMAi HCFNVES.
OrthoDBi EOG6Z9B18.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00027 .
BioCyci AVAR240292:GCY3-922-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_02120. LysA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PRINTSi PR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01048. lysA. 1 hit.
PROSITEi PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiQ3MEQ0_ANAVT
AccessioniPrimary (citable) accession number: Q3MEQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2005
Last sequence update: October 25, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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