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Protein

Diaminopimelate decarboxylase

Gene

lysA

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes L-lysine from DL-2,6-diaminopimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Diaminopimelate decarboxylase (lysA)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from DL-2,6-diaminopimelate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei275Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei320SubstrateUniRule annotation1
Binding sitei357SubstrateUniRule annotation1
Binding sitei361SubstrateUniRule annotation1
Binding sitei389SubstrateUniRule annotation1
Binding sitei417Pyridoxal phosphateUniRule annotation1
Binding sitei417SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, Lyase
Biological processAmino-acid biosynthesis, Lysine biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-7990-MONOMER
UniPathwayiUPA00034; UER00027

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
Short name:
DAP decarboxylaseUniRule annotation
Short name:
DAPDCUniRule annotation
Gene namesi
Name:lysAUniRule annotation
Ordered Locus Names:Ava_0912Imported
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)Imported
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi
  • UP000002533 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi240292.Ava_0912

Structurei

3D structure databases

ProteinModelPortaliQ3MEQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 324Orn_Arg_deC_NInterPro annotationAdd BLAST242
Domaini298 – 415Orn_DAP_Arg_deCInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni317 – 320Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CU5 Bacteria
COG0019 LUCA
HOGENOMiHOG000045071
KOiK01586
OMAiVVGYICE
OrthoDBiPOG091H013X

Family and domain databases

CDDicd06828 PLPDE_III_DapDC, 1 hit
Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_02120 LysA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002986 DAP_deCOOHase_LysA
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43727:SF2 PTHR43727:SF2, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01181 DAPDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01048 lysA, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3MEQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSTHPAGVQ DAGTQYLPQR RNTNTNISPN QELLPLTAKA NSQGNLEIGG
60 70 80 90 100
CDVTTLVEQF GSPLYILDEE TLRTACQQYR DGFQKYYPGE SQVLYASKAW
110 120 130 140 150
NCLAVCAIAG SEGLGIDVVS GGELYTALAA GVSPAKIYLH GNNKSREELI
160 170 180 190 200
LAIESGVTIV ADNWYELRTL ASLTHTDQPV RIMLRLTPGI ECHTHEYIRT
210 220 230 240 250
GHLDSKFGFD PNDLAEVFEF VSQQPNLNCV GLHAHIGSQI FERQPHRDLA
260 270 280 290 300
AVMVQWLRDA NKYGLNVTEL NVGGGLGIKY VESDDPPSID EWVKAICEVV
310 320 330 340 350
QSACAAENLP LPKLLSEPGR SLIATSCVTA YTVGSSKTIP EIRTYVSIDG
360 370 380 390 400
GMSDNPRPIT YQSVYRAVIA NKLSVSHTET VTIAGKHCES GDILIKNAQL
410 420 430 440 450
PKTEPGDILV VMATGAYNYS MASNYNRLPR PAAVVVANGE ANLILQRETY
460
QDLIRQDCLP ERLK
Length:464
Mass (Da):50,665
Last modified:October 25, 2005 - v1
Checksum:i0027FB30BE673B0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA Translation: ABA20536.1

Genome annotation databases

EnsemblBacteriaiABA20536; ABA20536; Ava_0912
KEGGiava:Ava_0912

Similar proteinsi

Entry informationi

Entry nameiQ3MEQ0_ANAVT
AccessioniPrimary (citable) accession number: Q3MEQ0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2005
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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