Reviewed, UniProtKB/Swiss-Prot Q3MEJ8 (PANCY_ANAVT)

Names and origin

Protein names

Recommended name:
    Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
    1- Recommended name:
            Pantoate--beta-alanine ligase
              EC=6.3.2.1
        Alternative name(s):
            Pantothenate synthetase
            Pantoate-activating enzyme
    2- Recommended name:
            Cytidylate kinase
                Short name=CK
              EC=2.7.4.14
        Alternative name(s):
            Cytidine monophosphate kinase
              Short name=CMP kinase

Gene names

Name:	panC/cmk
Ordered Locus Names:	Ava_0964

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	534 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_01349 ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_01349
Pathway	Cofactor biosynthesis; pantothenate biosynthesis; pantothenate from beta-alanine and pantoate: step 1/1. HAMAP MF_01349
Subcellular location	Cytoplasm By similarity.
Sequence similarities	In the N-terminal section; belongs to the pantothenate synthetase family. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Ligase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: HAMAP pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activity Inferred from electronic annotation. Source: HAMAP pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 534	534	Bifunctional pantoate ligase/cytidylate kinase HAMAP MF_01349		PRO_0000239786
Regions
	Nucleotide binding	315 – 323	9	ATP By similarity
	Region	1 – 302	302	Pantoate--beta-alanine ligase HAMAP MF_01349
	Region	303 – 534	232	Cytidylate kinase HAMAP MF_01349

Sequences

	Sequence		Length	Mass (Da)
	Q3MEJ8-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 60E70FEF5A9B4CA6	FASTA	534	59,145
	10 20 30 40 50 60 MRLLTTVAAL RCYLNKRRWE SQLTASEEQI LDSMTSWYQT AIGLVPTMGS LHQGHLSLIE 70 80 90 100 110 120 RARHENSTVI VSIFINPLQF GPNEDYGRYP RTLEQDRQLC EQAGVDAIFA PSPEELGIPQ 130 140 150 160 170 180 KNIQESQVTQ VIPPSVMISG LCGHSRLGHF QGVATIVTKL LNLVQPDRAY FGQKDGQQLA 190 200 210 220 230 240 VIKRLVADLN LPVEIVACPT VREASGLACS SRNQYLTAPE KQQAAVLYRG LLQAEAAFKA 250 260 270 280 290 300 GVRYSSRLRE VVRQELAKVS SVLVEYIELV EPTTLMPLDK IQEEGMLAIA ARLGSTRLID 310 320 330 340 350 360 NTILRDRQPI IAIDGPAGAG KSTVARQVAT KLGLVYLDTG AMYRAVTWLV LQQGIAIDDD 370 380 390 400 410 420 CAIAELANNC KIELTPSQDL QSPVRVWIND TDVTQDIRTI EVTSQVSAIA AQAAVREALV 430 440 450 460 470 480 KQQQRWGKRG GLVAEGRDIG THVFPDAEVK IFLTASVGER ARRRQQDFQK QGQPEVSLEQ 490 500 510 520 530 LEKDIAERDW KDSTRKVSPL QKAADAVELQ TDGLSISDVA SQIVDYYQQR LSQW

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA20588.1.
RefSeq	YP_321483.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3680227.
GenomeReviews	Gene locus Ava_0964 in contig CP000117_GR.
KEGG	ava:Ava_0964.
NMPDR	fig|240292.3.peg.170.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3MEJ8.
OMA	Q3MEJ8. LGEKDWQ.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_0964-MON.
Family and domain databases
HAMAP	MF_01349. [Tree]
InterPro	IPR004821. Cyt_trans_rel. IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kin_d. IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. PF02569. Pantoate_ligase. 1 hit. [Graphical view]
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00017. cmk. 1 hit. TIGR00125. cyt_tran_rel. 1 hit. TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANCY_ANAVT

Accession

Primary (citable) accession number: Q3MEJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)