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Q3MEJ8

- PANCY_ANAVT

UniProt

Q3MEJ8 - PANCY_ANAVT

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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene
panC/cmk, Ava_0964
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi315 – 3239ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-974-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Ordered Locus Names:Ava_0964
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Bifunctional pantoate ligase/cytidylate kinaseUniRule annotationPRO_0000239786Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_0964.

Structurei

3D structure databases

ProteinModelPortaliQ3MEJ8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 302302Pantoate--beta-alanine ligaseUniRule annotationAdd
BLAST
Regioni303 – 534232Cytidylate kinaseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3MEJ8-1 [UniParc]FASTAAdd to Basket

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MRLLTTVAAL RCYLNKRRWE SQLTASEEQI LDSMTSWYQT AIGLVPTMGS    50
LHQGHLSLIE RARHENSTVI VSIFINPLQF GPNEDYGRYP RTLEQDRQLC 100
EQAGVDAIFA PSPEELGIPQ KNIQESQVTQ VIPPSVMISG LCGHSRLGHF 150
QGVATIVTKL LNLVQPDRAY FGQKDGQQLA VIKRLVADLN LPVEIVACPT 200
VREASGLACS SRNQYLTAPE KQQAAVLYRG LLQAEAAFKA GVRYSSRLRE 250
VVRQELAKVS SVLVEYIELV EPTTLMPLDK IQEEGMLAIA ARLGSTRLID 300
NTILRDRQPI IAIDGPAGAG KSTVARQVAT KLGLVYLDTG AMYRAVTWLV 350
LQQGIAIDDD CAIAELANNC KIELTPSQDL QSPVRVWIND TDVTQDIRTI 400
EVTSQVSAIA AQAAVREALV KQQQRWGKRG GLVAEGRDIG THVFPDAEVK 450
IFLTASVGER ARRRQQDFQK QGQPEVSLEQ LEKDIAERDW KDSTRKVSPL 500
QKAADAVELQ TDGLSISDVA SQIVDYYQQR LSQW 534
Length:534
Mass (Da):59,145
Last modified:October 25, 2005 - v1
Checksum:i60E70FEF5A9B4CA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA20588.1.
RefSeqiWP_011317818.1. NC_007413.1.
YP_321483.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA20588; ABA20588; Ava_0964.
GeneIDi3680227.
KEGGiava:Ava_0964.
PATRICi35422386. VBIAnaVar43351_1758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA20588.1 .
RefSeqi WP_011317818.1. NC_007413.1.
YP_321483.1. NC_007413.1.

3D structure databases

ProteinModelPortali Q3MEJ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240292.Ava_0964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA20588 ; ABA20588 ; Ava_0964 .
GeneIDi 3680227.
KEGGi ava:Ava_0964.
PATRICi 35422386. VBIAnaVar43351_1758.

Phylogenomic databases

eggNOGi COG0283.
HOGENOMi HOG000233355.
KOi K13799.
OMAi LGEKDWQ.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci AVAR240292:GCY3-974-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProi IPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfami PF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiPANCY_ANAVT
AccessioniPrimary (citable) accession number: Q3MEJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 25, 2005
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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