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Q3MEJ8

- PANCY_ANAVT

UniProt

Q3MEJ8 - PANCY_ANAVT

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
    ATP + (d)CMP = ADP + (d)CDP.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi315 – 3239ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAVAR240292:GCY3-974-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinase
    Including the following 2 domains:
    Pantoate--beta-alanine ligase (EC:6.3.2.1)
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
    Cytidylate kinase (EC:2.7.4.14)
    Short name:
    CK
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name:
    CMP kinase
    Gene namesi
    Name:panC/cmk
    Ordered Locus Names:Ava_0964
    OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
    Taxonomic identifieri240292 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
    ProteomesiUP000002533: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 534534Bifunctional pantoate ligase/cytidylate kinasePRO_0000239786Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi240292.Ava_0964.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MEJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 302302Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni303 – 534232Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.Curated
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0283.
    HOGENOMiHOG000233355.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3MEJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLLTTVAAL RCYLNKRRWE SQLTASEEQI LDSMTSWYQT AIGLVPTMGS    50
    LHQGHLSLIE RARHENSTVI VSIFINPLQF GPNEDYGRYP RTLEQDRQLC 100
    EQAGVDAIFA PSPEELGIPQ KNIQESQVTQ VIPPSVMISG LCGHSRLGHF 150
    QGVATIVTKL LNLVQPDRAY FGQKDGQQLA VIKRLVADLN LPVEIVACPT 200
    VREASGLACS SRNQYLTAPE KQQAAVLYRG LLQAEAAFKA GVRYSSRLRE 250
    VVRQELAKVS SVLVEYIELV EPTTLMPLDK IQEEGMLAIA ARLGSTRLID 300
    NTILRDRQPI IAIDGPAGAG KSTVARQVAT KLGLVYLDTG AMYRAVTWLV 350
    LQQGIAIDDD CAIAELANNC KIELTPSQDL QSPVRVWIND TDVTQDIRTI 400
    EVTSQVSAIA AQAAVREALV KQQQRWGKRG GLVAEGRDIG THVFPDAEVK 450
    IFLTASVGER ARRRQQDFQK QGQPEVSLEQ LEKDIAERDW KDSTRKVSPL 500
    QKAADAVELQ TDGLSISDVA SQIVDYYQQR LSQW 534
    Length:534
    Mass (Da):59,145
    Last modified:October 25, 2005 - v1
    Checksum:i60E70FEF5A9B4CA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000117 Genomic DNA. Translation: ABA20588.1.
    RefSeqiWP_011317818.1. NC_007413.1.
    YP_321483.1. NC_007413.1.

    Genome annotation databases

    EnsemblBacteriaiABA20588; ABA20588; Ava_0964.
    GeneIDi3680227.
    KEGGiava:Ava_0964.
    PATRICi35422386. VBIAnaVar43351_1758.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000117 Genomic DNA. Translation: ABA20588.1 .
    RefSeqi WP_011317818.1. NC_007413.1.
    YP_321483.1. NC_007413.1.

    3D structure databases

    ProteinModelPortali Q3MEJ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 240292.Ava_0964.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA20588 ; ABA20588 ; Ava_0964 .
    GeneIDi 3680227.
    KEGGi ava:Ava_0964.
    PATRICi 35422386. VBIAnaVar43351_1758.

    Phylogenomic databases

    eggNOGi COG0283.
    HOGENOMi HOG000233355.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci AVAR240292:GCY3-974-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Anabaena variabilis ATCC 29413."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29413 / PCC 7937.

    Entry informationi

    Entry nameiPANCY_ANAVT
    AccessioniPrimary (citable) accession number: Q3MEJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3