Q3MEA8 (GUAA_ANAVT) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 49.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: GMP synthase [glutamine-hydrolyzing] EC=6.3.5.2 Alternative name(s): GMP synthetase Glutamine amidotransferase | ||||
| Gene names |
| ||||
| Organism | Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 240292 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena |
Protein attributes
| Sequence length | 540 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00344 |
| Catalytic activity | ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00344 |
| Pathway | Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00344 |
| Subunit structure | Homodimer By similarity. HAMAP MF_00344 |
| Sequence similarities | Contains 1 glutamine amidotransferase type-1 domain. Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | GMP biosynthesis Purine biosynthesis |
| Domain | Glutamine amidotransferase |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | GMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW asparagine biosynthetic processInferred from electronic annotation. Source: InterPro glutamine metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GMP synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: EC asparagine synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 540 | 540 | GMP synthase [glutamine-hydrolyzing] HAMAP MF_00344 | PRO_0000229397 | |||||
Regions | |||||||||
| Domain | 26 – 216 | 191 | Glutamine amidotransferase type-1 | ||||||
| Domain | 217 – 415 | 199 | GMPS ATP-PPase | ||||||
| Nucleotide binding | 244 – 250 | 7 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 103 | 1 | Nucleophile By similarity | ||||||
| Active site | 190 | 1 | By similarity | ||||||
| Active site | 192 | 1 | By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29413 / PCC 7937. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000117 Genomic DNA. Translation: ABA20678.1. |
| RefSeq | YP_321573.1. NC_007413.1. |
3D structure databases | |
| ProteinModelPortal | Q3MEA8. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3MEA8. |
Protein family/group databases | |
| MEROPS | C26.A17. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3678606. |
| GenomeReviews | Gene locus Ava_1054 in contig CP000117_GR. |
| KEGG | ava:Ava_1054. |
| NMPDR | fig|240292.3.peg.264. |
| PATRIC | 35422604. VBIAnaVar43351_1865. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0519. |
| HOGENOM | HBG391775. |
| OMA | DGRTYEY. |
| PhylomeDB | Q3MEA8. |
| ProtClustDB | PRK00074. |
Enzyme and pathway databases | |
| BioCyc | AVAR240292:AVA_1054-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00344. GMP_synthase. [Tree] |
| InterPro | IPR001962. Asn_synthase. IPR017926. GATASE_1. IPR001674. GMP_synth_C. IPR004739. GMP_synth_N. IPR022955. GMP_synthase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| KO | K01951. |
| Pfam | PF00733. Asn_synthase. 1 hit. PF00117. GATase. 1 hit. PF00958. GMP_synt_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00884. GuaA_Cterm. 1 hit. TIGR00888. GuaA_Nterm. 1 hit. |
| PROSITE | PS51273. GATASE_TYPE_1. 1 hit. PS51553. GMPS_ATP_PPASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GUAA_ANAVT | ||||||||
| Accession | Primary (citable) accession number: Q3MEA8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with