Reviewed, UniProtKB/Swiss-Prot Q3MDY8 (PYRB_ANAVT)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Ava_1174

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321069

Sequences

	Sequence		Length	Mass (Da)
	Q3MDY8-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 7B6D387DA0A1E2AF	FASTA	333	36,582
	10 20 30 40 50 60 MPTSTWNRHH VLSLADFTAA EYDIVLKTAA SFQEVLSRRT KKVPALQGQV VANLFFEPST 70 80 90 100 110 120 RTRSSFELAA KRLSADTLNF AASTSSMTKG ETILDTAKTY LAMGTDIMVI RHKEAGVPNA 130 140 150 160 170 180 IAQEMDRLGV RVSVLNAGDG QHEHPSQGLL DLFTICSLVD PANPRLELLQ GKKIAIVGDI 190 200 210 220 230 240 LHSRVARSNI WSLIASGAQV HLAAPPTLLP KLFAEYIFGE ETAPPGQLFI HWQLEPALQD 250 260 270 280 290 300 ADFVMTLRLQ KERMTAHLLP SLREYHQLFG ITRAKLQLCQ PNVKVLHPGP VNRGVEISSD 310 320 330 LMDDPEFSLI QSQVTSGVAV RMALLYLIGS GKT

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000117 Genomic DNA. Translation: ABA20798.1.
RefSeq	YP_321693.1.
3D structure databases
HSSP	HSSP built from PDB template 2AIR based on UniProtKB P0A786.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MDY8.
Genome annotation databases
GeneID	3683312.
GenomeReviews	Gene locus Ava_1174 in contig CP000117_GR.
KEGG	ava:Ava_1174.
NMPDR	fig|240292.3.peg.1699.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	VMMLRVQ.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_1174-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ANAVT

Accession

Primary (citable) accession number: Q3MDY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 25, 2005
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)