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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-8667-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Ava_1267
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
Proteomesi
  • UP000002533 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Transmembranei49 – 69HelicalUniRule annotationAdd BLAST21
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei119 – 139HelicalUniRule annotationAdd BLAST21
Transmembranei154 – 174HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 203HelicalUniRule annotationAdd BLAST21
Transmembranei215 – 235HelicalUniRule annotationAdd BLAST21
Transmembranei237 – 257HelicalUniRule annotationAdd BLAST21
Transmembranei281 – 301HelicalUniRule annotationAdd BLAST21
Transmembranei347 – 367HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002354351 – 367Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST367

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_1267.

Structurei

3D structure databases

SMRiQ3MDP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3MDP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKLSPNQG LNISGIGLAS SLAAGLGIAA LTLDWIANRN PWQGTSLTLP
60 70 80 90 100
LLLCTIASAI AGYFVVPLLQ ALKTGQIIRE DGPQAHLKKA GTPTMGGIFF
110 120 130 140 150
IPVAVVGACV LSNFATEVLA VSALTLSYGL IGWIDDWQIL RRKSNKGISP
160 170 180 190 200
RMKLALQICF AAAFCLWLMF NQPANITSIA LPWVSFALPL GFLFWPLAGF
210 220 230 240 250
VLVAESNATN LTDGIDGLAG GTVAIALLAL GAIVAPTSPA LMVFCAALSG
260 270 280 290 300
SCLGFLAHNR NPARVFMGDT GSLALGGALA AVALLTNSLV ALFILSGIFF
310 320 330 340 350
VETLSVMAQV SYYKATKGPD GKGKRLLKMA PLHHHLELSG WSELQVVSSF
360
YVIATILAVI CLAIAPF
Length:367
Mass (Da):38,393
Last modified:October 25, 2005 - v1
Checksum:iDAB550360C7D26C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA20891.1.

Genome annotation databases

EnsemblBacteriaiABA20891; ABA20891; Ava_1267.
KEGGiava:Ava_1267.

Similar proteinsi

Entry informationi

Entry nameiMRAY_ANAVT
AccessioniPrimary (citable) accession number: Q3MDP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 25, 2005
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families