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Q3MDP5 (MRAY_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:Ava_1267
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000235435

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane119 – 13921Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane215 – 23521Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane281 – 30121Helical; Potential
Transmembrane347 – 36721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q3MDP5 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: DAB550360C7D26C1

FASTA36738,393
        10         20         30         40         50         60 
MDAKLSPNQG LNISGIGLAS SLAAGLGIAA LTLDWIANRN PWQGTSLTLP LLLCTIASAI 

        70         80         90        100        110        120 
AGYFVVPLLQ ALKTGQIIRE DGPQAHLKKA GTPTMGGIFF IPVAVVGACV LSNFATEVLA 

       130        140        150        160        170        180 
VSALTLSYGL IGWIDDWQIL RRKSNKGISP RMKLALQICF AAAFCLWLMF NQPANITSIA 

       190        200        210        220        230        240 
LPWVSFALPL GFLFWPLAGF VLVAESNATN LTDGIDGLAG GTVAIALLAL GAIVAPTSPA 

       250        260        270        280        290        300 
LMVFCAALSG SCLGFLAHNR NPARVFMGDT GSLALGGALA AVALLTNSLV ALFILSGIFF 

       310        320        330        340        350        360 
VETLSVMAQV SYYKATKGPD GKGKRLLKMA PLHHHLELSG WSELQVVSSF YVIATILAVI 


CLAIAPF

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References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000117 Genomic DNA. Translation: ABA20891.1.
RefSeqYP_321786.1. NC_007413.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ3MDP5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3683166.
GenomeReviewsGene locus Ava_1267 in contig CP000117_GR.
KEGGava:Ava_1267.
NMPDRfig|240292.3.peg.1951.
PATRIC35423075. VBIAnaVar43351_2099.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMAGMISKTT.
PhylomeDBQ3MDP5.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycAVAR240292:AVA_1267-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ANAVT
AccessionPrimary (citable) accession number: Q3MDP5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 25, 2005
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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