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Protein

Malate dehydrogenase

Gene

mdh

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45NADUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Binding sitei107NADUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Active sitei187Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 26NADUniRule annotation6
Nucleotide bindingi130 – 132NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-8673-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Ava_1273
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi
  • UP000002533 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419381 – 324Malate dehydrogenaseAdd BLAST324

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_1273

Structurei

3D structure databases

ProteinModelPortaliQ3MDN9
SMRiQ3MDN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiRQPGQTR
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.101 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q3MDN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSPDSPPI LHRLPRVAII GAGRVGSTLA QRIAEKNLAD VVLLDIVEGM
60 70 80 90 100
PQGLALDLLE ARGIELHNRQ IIGTNNYADT SGSQIVVITA GFPRKPGMSR
110 120 130 140 150
DDLLRTNAKI VVEAAKQAIA YSPCAIFIVV TNPLDVMTYL AWEATGLPRN
160 170 180 190 200
RIMGMAGVLD SARFETFIAL ELGVLPADVK AMVLGSHGDL MVPLSRHATV
210 220 230 240 250
NGIPITELLD AATIERLVER TRNGGAEIVE LMQTGGAFFA PASATSLMVE
260 270 280 290 300
SILLNQSRLL PVSVYLQGEY GLKDVVIGVP CRLGLNGIES VIELNLSDSE
310 320
REALQTSAQS VQKNIERWHS TQHS
Length:324
Mass (Da):34,804
Last modified:October 25, 2005 - v1
Checksum:iE6C8A990378DCF39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA Translation: ABA20897.1

Genome annotation databases

EnsemblBacteriaiABA20897; ABA20897; Ava_1273
KEGGiava:Ava_1273

Similar proteinsi

Entry informationi

Entry nameiMDH_ANAVT
AccessioniPrimary (citable) accession number: Q3MDN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 25, 2005
Last modified: February 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome