Reviewed, UniProtKB/Swiss-Prot Q3MD38 (KGUA_ANAVT)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Ava_1475

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Guanylate kinase HAMAP MF_00328		PRO_0000266283
Regions
	Domain	20 – 198	179	Guanylate kinase-like
	Nucleotide binding	27 – 34	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3MD38-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 7068263B8F1DB6CE	FASTA	199	22,045
	10 20 30 40 50 60 MMQVLSIQNC ATTKENPSSG KLIVLTGPSG VGKGTLMRSL LQRHPELYYS VSATTRAPRP 70 80 90 100 110 120 GEVNGESYYF ISRNKFEELL AQGEFLESAE FAGNYYGTPR EAVLNQIQSG KLVVLEIELA 130 140 150 160 170 180 GARQIRASFP EALSIFILPP SFEELEKRIR GRGQDSEEAI ARRLQRATEE IQAADEFDIQ 190 IVNDDFEAAL QAIEVALFG

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA21098.1.
RefSeq	YP_321993.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MD38.
Genome annotation databases
GeneID	3682518.
GenomeReviews	Gene locus Ava_1475 in contig CP000117_GR.
KEGG	ava:Ava_1475.
NMPDR	fig|240292.3.peg.3176.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3MD38.
OMA	EWAEFAG.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_1475-MON.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_ANAVT

Accession

Primary (citable) accession number: Q3MD38

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 25, 2005
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)