Reviewed, UniProtKB/Swiss-Prot Q3MD34 (GCP_ANAVT)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	Ava_1479

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303253
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3MD34-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 9AD6D7EC7F8E18F3	FASTA	346	36,319
	10 20 30 40 50 60 MTTVLAIETS CDETAVAIVN NRQVCSSIIA SQIPVHQQYG GVVPEVASRA HLETINDAIA 70 80 90 100 110 120 QAMDQAQLGW DKIDGIAATC APGLVGALLV GLTAAKTLAI LHNKPFLGVH HLEGHIYATY 130 140 150 160 170 180 LSEPTLDPPF LSLLVSGGHT SLIYVKECGR YESLGETRDD AAGEAFDKVA RLLKLGYPGG 190 200 210 220 230 240 PVIDKLAQTG NSQAFALPEG KVSLAGGGYH PYDGSFSGLK TAVLRLVQQL ERDGDPLPIE 250 260 270 280 290 300 DISASFQATV AKALTKRAIA CALDYGLDTI AVGGGVAANS GLRQHLQAAA TANNLRVLFP 310 320 330 340 PLKFCTDNAA MIACAAADHL SRGHLSPITL GVESRLSLSQ VMKLYQ

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA21102.1.
RefSeq	YP_321997.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MD34.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	3682522.
GenomeReviews	Gene locus Ava_1479 in contig CP000117_GR.
KEGG	ava:Ava_1479.
NMPDR	fig|240292.3.peg.3180.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3MD34.
OMA	EHSAYGG.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_1479-MON.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ANAVT

Accession

Primary (citable) accession number: Q3MD34

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 25, 2005
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)