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Q3MCT9 (HEMH_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Ava_1574
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Ferrochelatase HAMAP MF_00323
PRO_1000019272

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3MCT9 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: A220751221FE742C

FASTA38844,129
        10         20         30         40         50         60 
MGRVGVLLLN LGGPDKLEDV GPFLFNLFSD PEIIRLPFRW LQKPLAWFIA SRRTKTSQEN 

        70         80         90        100        110        120 
YKQIGGGSPL RRITEAQGEA LKEQLHDLGQ EANIYVGMRY WHPYTEEAIA LLTQDNLDNL 

       130        140        150        160        170        180 
VILPLYPQFS ISTSGSSFRL LERLWQEDPK LQRLDYTVIP SWYKEPCYLQ AMAELISQEV 

       190        200        210        220        230        240 
DQFPDPDQVH VFFSAHGVPK SYVEEAGDPY QQEIEECTAL IMQTLNRPNP HTLAYQSRVG 

       250        260        270        280        290        300 
PVEWLQPYTE DALKELGAQG VKDLVVVPIS FVSEHIETLQ EIDIEYREIA EEAGIHNFRR 

       310        320        330        340        350        360 
VAAPNTHPVF IRALANLVID ALNKPSFKLS QAAQIKKMVK MYPPESWEWG MTSSAEVWNG 

       370        380 
RIAMLGFIAL IIELVTGQGL LHMIGLLQ

« Hide

References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000117 Genomic DNA. Translation: ABA21197.1.
RefSeqYP_322092.1. NC_007413.1.

3D structure databases

ProteinModelPortalQ3MCT9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3MCT9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3681117.
GenomeReviewsGene locus Ava_1574 in contig CP000117_GR.
KEGGava:Ava_1574.
NMPDRfig|240292.3.peg.2655.
PATRIC35423773. VBIAnaVar43351_2445.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBQ3MCT9.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycAVAR240292:AVA_1574-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_ANAVT
AccessionPrimary (citable) accession number: Q3MCT9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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