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Reviewed, UniProtKB/Swiss-Prot Q3MCT9 (HEMH_ANAVT)

Last modified February 9, 2010. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase
Gene names
Name: hemH
Ordered Locus Names: Ava_1574
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

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Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

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Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Ferrochelatase HAMAP MF_00323
PRO_1000019272

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3MCT9-1 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: A220751221FE742C

FASTA38844,129
        10         20         30         40         50         60 
MGRVGVLLLN LGGPDKLEDV GPFLFNLFSD PEIIRLPFRW LQKPLAWFIA SRRTKTSQEN 

        70         80         90        100        110        120 
YKQIGGGSPL RRITEAQGEA LKEQLHDLGQ EANIYVGMRY WHPYTEEAIA LLTQDNLDNL 

       130        140        150        160        170        180 
VILPLYPQFS ISTSGSSFRL LERLWQEDPK LQRLDYTVIP SWYKEPCYLQ AMAELISQEV 

       190        200        210        220        230        240 
DQFPDPDQVH VFFSAHGVPK SYVEEAGDPY QQEIEECTAL IMQTLNRPNP HTLAYQSRVG 

       250        260        270        280        290        300 
PVEWLQPYTE DALKELGAQG VKDLVVVPIS FVSEHIETLQ EIDIEYREIA EEAGIHNFRR 

       310        320        330        340        350        360 
VAAPNTHPVF IRALANLVID ALNKPSFKLS QAAQIKKMVK MYPPESWEWG MTSSAEVWNG 

       370        380 
RIAMLGFIAL IIELVTGQGL LHMIGLLQ

« Hide

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References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000117 Genomic DNA. Translation: ABA21197.1.
RefSeqYP_322092.1.

3D structure databases

SMRQ3MCT9. Positions 2-328.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3MCT9.

Genome annotation databases

GeneID3681117.
GenomeReviewsGene locus Ava_1574 in contig CP000117_GR.
KEGGava:Ava_1574.
NMPDRfig|240292.3.peg.2655.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMAWLQKPLA.
PhylomeDBQ3MCT9.

Enzyme and pathway databases

BioCycAVAR240292:AVA_1574-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. hemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHEMH_ANAVT
AccessionPrimary (citable) accession number: Q3MCT9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: February 9, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents