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Reviewed, UniProtKB/Swiss-Prot Q3MC76 (DCUP_ANAVT)

Last modified February 9, 2010. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: Ava_1788
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

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Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023870

Regions

Region28 – 325Substrate binding By similarity

Sites

Binding site781Substrate By similarity
Binding site1551Substrate By similarity
Binding site2101Substrate By similarity
Binding site3251Substrate By similarity
Site781Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3MC76-1 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: 5BF7EBC98A08B687

FASTA35038,823
        10         20         30         40         50         60 
MGVTSTAPHL LRAARGEIVD RPPVWMMRQA GRYMKAYRDL REKYPSFRDR SEIPEVAIEV 

        70         80         90        100        110        120 
SLQPWKAFQP DGVILFSDIV TPLPGLGIEM DIAEGKGPII HAPIRTQAQI EQLRPLEPEA 

       130        140        150        160        170        180 
ALPFIKTILQ ALRQEVGHQS TVLGFVGAPW TLAAYAVEGK GSKTYSIIKN LAFSEPAILH 

       190        200        210        220        230        240 
QLLTKLADAI AIYARYQIDS GAQVVQMFDS WAGQLSPQDY DTFALPYQQR VFQQIKQTHP 

       250        260        270        280        290        300 
DTPLILLVSG SAGVLERMGQ SGADIVTVDW TVDMADARAR LGKQMKVQGN LDPGVLYASK 

       310        320        330        340        350 
QFIRDRIIDT VRKAGNWGHI LNLGHGVLPD TPEENVAFFF ETAKQLNVLV

« Hide

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References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000117 Genomic DNA. Translation: ABA21410.1.
RefSeqYP_322305.1.

3D structure databases

SMRQ3MC76. Positions 6-346.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3MC76.

Genome annotation databases

GeneID3682072.
GenomeReviewsGene locus Ava_1788 in contig CP000117_GR.
KEGGava:Ava_1788.
NMPDRfig|240292.3.peg.2868.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAQIFDTWG.
PhylomeDBQ3MC76.

Enzyme and pathway databases

BioCycAVAR240292:AVA_1788-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_ANAVT
AccessionPrimary (citable) accession number: Q3MC76
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents