Reviewed, UniProtKB/Swiss-Prot Q3MC57 (ARLY_ANAVT)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Ava_1807

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Argininosuccinate lyase HAMAP MF_00006		PRO_0000240709

Sequences

	Sequence		Length	Mass (Da)
	Q3MC57-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 5A9438DCF7A25E10	FASTA	461	51,627
	10 20 30 40 50 60 MTEKQTWSQR FESALHPAIA LFNASISFDI ELIEYDLTGS QAHAQMLAHT GIISPAEGEQ 70 80 90 100 110 120 LVAGLEQIRE EYRQGKFQPG IDAEDVHFAV ERRLTEIVGD VGKKLHTARS RNDQVGTDTR 130 140 150 160 170 180 LYLRDQISQI KTQLREFQRV LLDIAEQNVE TLIPGYTHLQ RAQPVSLAHH LLAYFHMAQR 190 200 210 220 230 240 DWERLGDVYR RVNISPLGCG ALAGTTFPID RHYTAKLLQF ERIYENSLDG VSDRDFAIEF 250 260 270 280 290 300 LCAASLIMVH LSRLSEEIIL WASEEFRFVT LKDSCATGSS IMPQKKNPDV PELVRGKTGR 310 320 330 340 350 360 VFGHLQAMLV IMKGLPLAYN KDLQEDKEGL FDSVNTVKAC LEAMTILLQE GLEFRTQRLA 370 380 390 400 410 420 EAVTQDFSNA TDVADYLAAR GVPFREAYNI VGKVVKTSIA AGKLLKDLTL EEWQEIHPAF 430 440 450 460 ATDIYEAISP RQVVAARNSY GGTGFAQVSK AVSAAREEIG E

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA21429.1.
RefSeq	YP_322324.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3681974.
GenomeReviews	Gene locus Ava_1807 in contig CP000117_GR.
KEGG	ava:Ava_1807.
NMPDR	fig|240292.3.peg.2887.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3MC57.
OMA	Q3MC57. MAEDLIF.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_1807-MON.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. DCRYSTALLIN. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ANAVT

Accession

Primary (citable) accession number: Q3MC57

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)