ID   TRMD_ANAVT              Reviewed;         244 AA.
AC   Q3MC52;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
DE            EC=2.1.1.31;
DE   AltName: Full=M1G-methyltransferase;
DE   AltName: Full=tRNA [GM37] methyltransferase;
GN   Name=trmD; OrderedLocusNames=Ava_1812;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing N(1)-methylguanine.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase trmD family.
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DR   EMBL; CP000117; ABA21434.1; -; Genomic_DNA.
DR   RefSeq; YP_322329.1; -.
DR   GeneID; 3681979; -.
DR   GenomeReviews; CP000117_GR; Ava_1812.
DR   KEGG; ava:Ava_1812; -.
DR   NMPDR; fig|240292.3.peg.2892; -.
DR   HOGENOM; Q3MC52; -.
DR   OMA; Q3MC52; HRSVDDT.
DR   BioCyc; AVAR240292:AVA_1812-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0009019; F:tRNA (guanine-N1-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_00605; -; 1.
DR   InterPro; IPR016009; tRNA_m1G_MeTrfase.
DR   InterPro; IPR002649; tRNA_m1G_MeTrfase_bac.
DR   Pfam; PF01746; tRNA_m1G_MT; 1.
DR   PIRSF; PIRSF000386; tRNA_mtase; 1.
DR   ProDom; PD004978; tRNA_m1G_mtfrase; 1.
DR   TIGRFAMs; TIGR00088; trmD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing.
FT   CHAIN         1    244       tRNA (guanine-N(1)-)-methyltransferase.
FT                                /FTId=PRO_0000257387.
FT   REGION      131    136       S-adenosyl-L-methionine binding (By
FT                                similarity).
FT   BINDING     112    112       S-adenosyl-L-methionine; via amide
FT                                nitrogen (By similarity).
SQ   SEQUENCE   244 AA;  27417 MW;  ADCEBEAFF4794C29 CRC64;
     MRFDIVTLFP DCFTSVLSSG LLGKALAKQI AQVNLVNPRD FTTDKHRKVD DEPYGGGVGM
     LMKPEPIFSA VESLPILERR EVILMSPQGQ TIDQPLLREL VSNYEQLVVI CGHYEGVDDR
     VLHLVTREVS LGDFILTGGE IPAMALINGV VRLLPGTVAK TESLTAESFE EGLLDYPQYT
     RPANFRGWKV PDVLLSGNHA AISQWRYEQQ IKRTSDRRPD LLEKWQQEKK PGSREQGSRE
     QGEK
//