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Q3MBU3 (NADK1_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase 1

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase 1
Gene names
Name:nadK1
Ordered Locus Names:Ava_1921
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Sequence caution

The sequence ABA21543.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305NAD kinase 1 HAMAP-Rule MF_00361
PRO_0000229596

Regions

Nucleotide binding78 – 792NAD By similarity
Nucleotide binding152 – 1532NAD By similarity
Nucleotide binding193 – 1986NAD By similarity

Sites

Active site781Proton acceptor By similarity
Binding site1821NAD By similarity
Binding site2511NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3MBU3 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: BD8D1B4E5D7958BA

FASTA30532,830
        10         20         30         40         50         60 
MPKVGIIYND IKPVAGRVAI ELKDKLTTAG WDVSITSSIG GILGYSNPES PVCHTPIDGL 

        70         80         90        100        110        120 
TPPGFDSEMK FAIVLGGDGT VLAASRQVAP CGIPILAINT GHMGFLTETY LNQLPQAIDQ 

       130        140        150        160        170        180 
AIAGEYEIEE RAMLTVKVLR GESVLWEALC LNEMVLHREP LTSMCHFEIA VGRHAPVDIA 

       190        200        210        220        230        240 
ADGVIVSTPT GSTAYSLSAG GPVVTPGVPA LQLVPICPHS LASRALVFPD TEPVNIYPVN 

       250        260        270        280        290        300 
IPRLVMVVDG NGGCYIFPED RVYLERSPYS VKFIRLQPPE FFRILREKLG WGLPHIAKPT 


SVELP 

« Hide

References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000117 Genomic DNA. Translation: ABA21543.1. Different initiation.
RefSeqYP_322438.1. NC_007413.1.

3D structure databases

ProteinModelPortalQ3MBU3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING240292.Ava_1921.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA21543; ABA21543; Ava_1921.
GeneID3681698.
KEGGava:Ava_1921.
PATRIC35424527. VBIAnaVar43351_2821.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycAVAR240292:GCY3-1940-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK1_ANAVT
AccessionPrimary (citable) accession number: Q3MBU3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families