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Q3MBD8

- GLYA_ANAVT

UniProt

Q3MBD8 - GLYA_ANAVT

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Protein
Serine hydroxymethyltransferase
Gene
glyA, Ava_2076
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Pyridoxal phosphate By similarity
Binding sitei56 – 561Pyridoxal phosphate By similarity
Binding sitei58 – 581Substrate By similarity
Binding sitei65 – 651Substrate By similarity
Binding sitei66 – 661Pyridoxal phosphate By similarity
Binding sitei122 – 1221Substrate; via carbonyl oxygen By similarity
Binding sitei177 – 1771Pyridoxal phosphate By similarity
Binding sitei205 – 2051Pyridoxal phosphate By similarity
Binding sitei230 – 2301Pyridoxal phosphate By similarity
Binding sitei237 – 2371Pyridoxal phosphate By similarity
Binding sitei263 – 2631Pyridoxal phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei363 – 3631Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. glycine hydroxymethyltransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycine biosynthetic process from serine Source: UniProtKB-HAMAP
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, One-carbon metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-2099-MONOMER.
UniPathwayiUPA00193.
UPA00288; UER01023.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferase (EC:2.1.2.1)
Short name:
SHMT
Short name:
Serine methylase
Gene namesi
Name:glyA
Ordered Locus Names:Ava_2076
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Serine hydroxymethyltransferaseUniRule annotation
PRO_0000234944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi240292.Ava_2076.

Structurei

3D structure databases

ProteinModelPortaliQ3MBD8.
SMRiQ3MBD8. Positions 8-411.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1283Substrate binding By similarity
Regioni355 – 3573Substrate binding By similarity

Sequence similaritiesi

Belongs to the SHMT family.

Phylogenomic databases

eggNOGiCOG0112.
HOGENOMiHOG000239404.
KOiK00600.
OMAiCAYVNVQ.
OrthoDBiEOG6Z0QB2.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MBD8-1 [UniParc]FASTAAdd to Basket

« Hide

MTRTNSDFLT NSDPAIAGLI NQELQRQRDH LELIASENFT SAAVLAAQGS    50
VLTNKYAEGL PGKRYYGGCE FIDKIEQIAI DRAKQLFGAA HANVQPHSGA 100
QANFAVFLTL LAPGDKIMGM DLSHGGHLTH GSPVNVSGKW FQVCHYGVSQ 150
QTEQLDYDQI RELALRERPK LLICGYSAYP RIIDFEKFRS IADEVGAYLL 200
ADIAHIAGLV ASGLHPDPIP YCHVVTTTTH KTLRGPRGGL ILTGDAELGK 250
KLDKSVFPGS QGGPLEHVIA GKAVAFGEAL KPEFQGYSAQ VIENARALAN 300
QLQNRGLKLV SDGTDNHLML VDLRSVNMTG KRADQLVSEV NITANKNTVP 350
FDPQSPFVTS GLRLGSPAMT TRGMGEAEFT EIGNIIADRL LNPDSDTVAQ 400
DCKRRVAALC DRFPLYPHLE IPVPVLA 427
Length:427
Mass (Da):46,272
Last modified:October 25, 2005 - v1
Checksum:i11EF119715721354
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA21698.1.
RefSeqiYP_322593.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA21698; ABA21698; Ava_2076.
GeneIDi3680549.
KEGGiava:Ava_2076.
PATRICi35424891. VBIAnaVar43351_3000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA21698.1 .
RefSeqi YP_322593.1. NC_007413.1.

3D structure databases

ProteinModelPortali Q3MBD8.
SMRi Q3MBD8. Positions 8-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240292.Ava_2076.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA21698 ; ABA21698 ; Ava_2076 .
GeneIDi 3680549.
KEGGi ava:Ava_2076.
PATRICi 35424891. VBIAnaVar43351_3000.

Phylogenomic databases

eggNOGi COG0112.
HOGENOMi HOG000239404.
KOi K00600.
OMAi CAYVNVQ.
OrthoDBi EOG6Z0QB2.

Enzyme and pathway databases

UniPathwayi UPA00193 .
UPA00288 ; UER01023 .
BioCyci AVAR240292:GCY3-2099-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00051. SHMT.
InterProi IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view ]
PANTHERi PTHR11680. PTHR11680. 1 hit.
Pfami PF00464. SHMT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000412. SHMT. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00096. SHMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiGLYA_ANAVT
AccessioniPrimary (citable) accession number: Q3MBD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 25, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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