Reviewed, UniProtKB/Swiss-Prot Q3MB98 (SURE_ANAVT)

Names and origin

Protein names

Recommended name:
    5'-nucleotidase surE
    EC=3.1.3.5
Alternative name(s):
    Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	Ava_2116

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity. HAMAP MF_00060
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235588
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	40	1	Divalent metal cation By similarity
	Metal binding	98	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3MB98-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 4617D9FC80E910ED	FASTA	265	28,951
	10 20 30 40 50 60 MKLLISNDDG ISALGIRTLA NALAEVGHDV TVVCPDRERS ATGHGLTLHQ PIRAEIVESI 70 80 90 100 110 120 FHPAIKAWAC DGTPSDCVKL ALWALLDSPP DLVLSGINQG ANLGTEILYS GTVSAAMEGM 130 140 150 160 170 180 IEGIPSIAFS LTSHISRNFQ PAAKFATILV EQLAAKPIPD LMLLNVNIPP VEWEEIAGVK 190 200 210 220 230 240 LTRQGVRRYV DVFDKRTDPR GKTYYWLTGE VLEEVEPPEG LNLPQNVPID VHAVKDNYIS 250 260 ITPLQYNLTY ATALDKLSNW NFPMS

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000117 Genomic DNA. Translation: ABA21738.1.
RefSeq	YP_322633.1.
3D structure databases
SMR	Q3MB98. Positions 2-261.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MB98.
Genome annotation databases
GeneID	3680374.
GenomeReviews	Gene locus Ava_2116 in contig CP000117_GR.
KEGG	ava:Ava_2116.
NMPDR	fig|240292.3.peg.1715.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0496.
HOGENOM	HBG600532.
OMA	NLNIPPC.
PhylomeDB	Q3MB98.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_2116-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00087. surE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_ANAVT

Accession

Primary (citable) accession number: Q3MB98

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	October 25, 2005
Last modified:	February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)