Reviewed, UniProtKB/Swiss-Prot Q3MB19 (OTC_ANAVT)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	Ava_2197

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000065073
Regions
	Region	51 – 55	5	Carbamoyl phosphate binding By similarity
	Region	262 – 265	4	Ornithine binding By similarity
Sites
	Binding site	102	1	Carbamoyl phosphate By similarity
	Binding site	129	1	Carbamoyl phosphate By similarity
	Site	31	1	Important for structural integrity By similarity
	Site	142	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3MB19-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 643B720099D2BAA4	FASTA	306	33,400
	10 20 30 40 50 60 MAALLGRDLL SLADLTPTEL QELLQLATQL KSQQLKLRCN KVLGLLFSKA STRTRVSFTV 70 80 90 100 110 120 AMYQLGGQVI DLNPNVTQVS RGEPVQDTAR VLERYLDVLA IRTFEQQELA TFAEYAKIPV 130 140 150 160 170 180 INALTDLEHP CQILADLLTA QECFDTISGL TLTYVGDGNN VANSLMLGCA LAGMNVRIAT 190 200 210 220 230 240 PSGYEPNPQV VAQAQAIADG KTEILLTNDP ELATKGASVL YTDVWASMGQ EAEANDRFPI 250 260 270 280 290 300 FQPYQISEKL LSLAEPNAIV LHCLPAHRGE EITEEVIEGS QSRVWQQAEN RLHVQKALLA SILGAE

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000117 Genomic DNA. Translation: ABA21817.1.
RefSeq	YP_322712.1.
3D structure databases
HSSP	HSSP built from PDB template 1VLV based on UniProtKB P96108.
SMR	Q3MB19. Positions 1-305.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MB19.
Genome annotation databases
GeneID	3679754.
GenomeReviews	Gene locus Ava_2197 in contig CP000117_GR.
KEGG	ava:Ava_2197.
NMPDR	fig|240292.3.peg.2349.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	FTVAMYQ.
PhylomeDB	Q3MB19.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_2197-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_ANAVT

Accession

Primary (citable) accession number: Q3MB19

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 25, 2005
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)