Reviewed, UniProtKB/Swiss-Prot Q3MAX6 (HIS82_ANAVT)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	Ava_2242

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000230202
Amino acid modifications
	Modified residue	236	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3MAX6-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 97124B9B0046E6C7	FASTA	380	41,730
	10 20 30 40 50 60 MLPFIRSDLA QFTAYKPHPS SDTDAAVPAQ LDRLDTNESP CDLPPELKQK LAWTFQQVIE 70 80 90 100 110 120 SNRYPDGGHE ELKDAIAQYV NESANISSSP ITAANISVGN GSDELIRSLL IATCLGAQGS 130 140 150 160 170 180 ILVANPTFSM YGILAQTLGI PVVTVSRNPE NFEIDLTAAQ SAIEQTQNPP IRVVFVVHPN 190 200 210 220 230 240 SPTANPLTTN ELRWLKSLSE QILVVVDEAY FEFSQTTLIS ELVQRPNWVI LRTFSKAFRL 250 260 270 280 290 300 AAMRVGYCVA HPEAIAILEK VRLPYNLPSF SITSALVALQ NRAILLESIP QILNERAKLI 310 320 330 340 350 360 TALSKYPELA VAESAANFIF LQLKTDNKNS PDTALLNLHQ QLKNSGTLVR QISGGLRITI 370 380 GTPEENIRTL NHIQTALIKA

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA21860.1.
RefSeq	YP_322755.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3679316.
GenomeReviews	Gene locus Ava_2242 in contig CP000117_GR.
KEGG	ava:Ava_2242.
NMPDR	fig|240292.3.peg.2509.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3MAX6.
OMA	Q3MAX6. SNRYPDG.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_2242-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_ANAVT

Accession

Primary (citable) accession number: Q3MAX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)