ID   SYH_ANAVT               Reviewed;         462 AA.
AC   Q3MAV8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Histidyl-tRNA synthetase;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidine--tRNA ligase;
DE            Short=HisRS;
GN   Name=hisS; OrderedLocusNames=Ava_2260;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-histidine + tRNA(His) = AMP +
CC       diphosphate + L-histidyl-tRNA(His).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family.
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DR   EMBL; CP000117; ABA21878.1; -; Genomic_DNA.
DR   RefSeq; YP_322773.1; -.
DR   GeneID; 3679005; -.
DR   GenomeReviews; CP000117_GR; Ava_2260.
DR   KEGG; ava:Ava_2260; -.
DR   NMPDR; fig|240292.3.peg.2527; -.
DR   HOGENOM; Q3MAV8; -.
DR   OMA; Q3MAV8; RYDLTIP.
DR   BioCyc; AVAR240292:AVA_2260-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:HAMAP.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:HAMAP.
DR   HAMAP; MF_00127; -; 1.
DR   InterPro; IPR002314; aa-tRNA-synt_IIb_cons-reg.
DR   InterPro; IPR006195; aa-tRNA-synth_II_cons-reg.
DR   InterPro; IPR004154; Anticodon_bd.
DR   InterPro; IPR015807; His-tRNA-synth_IIa_sub.
DR   InterPro; IPR004516; His-tRNA_synth_IIA.
DR   Gene3D; G3DSA:3.40.50.800; Anticodon_bd; 1.
DR   PANTHER; PTHR11476; His-tRNA_synth; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF00587; tRNA-synt_2b; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;
KW   Ligase; Nucleotide-binding; Protein biosynthesis.
FT   CHAIN         1    462       Histidyl-tRNA synthetase.
FT                                /FTId=PRO_1000016310.
SQ   SEQUENCE   462 AA;  51555 MW;  E5D5EC197D229ED0 CRC64;
     MAKNDKINFS TPSGFPEFLP SEKRLELYLL DTIRRVYESY GFTPIETPAV ERLEVLQAKG
     NQGDNIIYGI DPILPPNRQA EKDKSGETGS EARALKFDQT VPLAAYIARH LNELTFPFAR
     YQMDVVFRGE RAKDGRFRQF RQCDIDVVGR EKLSLLYDAQ MPAIITEIFE AVHIGDFLIR
     INNRKVLTGF FQSLDISETQ IKSCISIIDN LEKIGEAKVK LELEKEGINP EQTQKIIDFI
     KIDGSVDDVL DKLKHLSQTL PESEQFNLGV SELETVITGV RNLGVPDKRF CIDLAIARGL
     NYYTGTVYET TLIGHEALGS ICSGGRYEEL VGTFIGEKMP GVGISIGLTR LISRLLKAGI
     LNTLPPTPAQ VVVVNMQDNL MPTYLKVSQQ LRQAGLNVIT NFEKRQLGKQ FQAADKQGIQ
     FCVIIGADEA AAQKSSLKDL KSGEQVEVAL ADLPEEVKRR LT
//