Reviewed, UniProtKB/Swiss-Prot Q3MAV8 (SYH_ANAVT)

Names and origin

Protein names

Recommended name:
    Histidyl-tRNA synthetase
    EC=6.1.1.21
Alternative name(s):
    Histidine--tRNA ligase
      Short name=HisRS

Gene names

Name:	hisS
Ordered Locus Names:	Ava_2260

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP MF_00127
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP histidine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Histidyl-tRNA synthetase HAMAP MF_00127		PRO_1000016310

Sequences

	Sequence		Length	Mass (Da)
	Q3MAV8-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: E5D5EC197D229ED0	FASTA	462	51,555
	10 20 30 40 50 60 MAKNDKINFS TPSGFPEFLP SEKRLELYLL DTIRRVYESY GFTPIETPAV ERLEVLQAKG 70 80 90 100 110 120 NQGDNIIYGI DPILPPNRQA EKDKSGETGS EARALKFDQT VPLAAYIARH LNELTFPFAR 130 140 150 160 170 180 YQMDVVFRGE RAKDGRFRQF RQCDIDVVGR EKLSLLYDAQ MPAIITEIFE AVHIGDFLIR 190 200 210 220 230 240 INNRKVLTGF FQSLDISETQ IKSCISIIDN LEKIGEAKVK LELEKEGINP EQTQKIIDFI 250 260 270 280 290 300 KIDGSVDDVL DKLKHLSQTL PESEQFNLGV SELETVITGV RNLGVPDKRF CIDLAIARGL 310 320 330 340 350 360 NYYTGTVYET TLIGHEALGS ICSGGRYEEL VGTFIGEKMP GVGISIGLTR LISRLLKAGI 370 380 390 400 410 420 LNTLPPTPAQ VVVVNMQDNL MPTYLKVSQQ LRQAGLNVIT NFEKRQLGKQ FQAADKQGIQ 430 440 450 460 FCVIIGADEA AAQKSSLKDL KSGEQVEVAL ADLPEEVKRR LT

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA21878.1.
RefSeq	YP_322773.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3679005.
GenomeReviews	Gene locus Ava_2260 in contig CP000117_GR.
KEGG	ava:Ava_2260.
NMPDR	fig|240292.3.peg.2527.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3MAV8.
OMA	Q3MAV8. RYDLTIP.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_2260-MON.
Family and domain databases
HAMAP	MF_00127. [Tree]
InterPro	IPR002314. aa-tRNA-synt_IIb_cons-reg. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004154. Anticodon_bd. IPR015807. His-tRNA-synth_IIa_sub. IPR004516. His-tRNA_synth_IIA. [Graphical view]
Gene3D	G3DSA:3.40.50.800. Anticodon_bd. 1 hit.
PANTHER	PTHR11476. His-tRNA_synth. 1 hit.
Pfam	PF03129. HGTP_anticodon. 1 hit. PF00587. tRNA-synt_2b. 1 hit. [Graphical view]
PIRSF	PIRSF001549. His-tRNA_synth. 1 hit.
TIGRFAMs	TIGR00442. hisS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYH_ANAVT

Accession

Primary (citable) accession number: Q3MAV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)