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Q3MAV8 (SYH_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase
EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:Ava_2260
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP MF_00127

Subunit structure

Homodimer By similarity. HAMAP MF_00127

Subcellular location

Cytoplasm By similarity HAMAP MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Histidine--tRNA ligase HAMAP MF_00127
PRO_1000016310

Sequences

Sequence LengthMass (Da)Tools
Q3MAV8 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: E5D5EC197D229ED0

FASTA46251,555
        10         20         30         40         50         60 
MAKNDKINFS TPSGFPEFLP SEKRLELYLL DTIRRVYESY GFTPIETPAV ERLEVLQAKG 

        70         80         90        100        110        120 
NQGDNIIYGI DPILPPNRQA EKDKSGETGS EARALKFDQT VPLAAYIARH LNELTFPFAR 

       130        140        150        160        170        180 
YQMDVVFRGE RAKDGRFRQF RQCDIDVVGR EKLSLLYDAQ MPAIITEIFE AVHIGDFLIR 

       190        200        210        220        230        240 
INNRKVLTGF FQSLDISETQ IKSCISIIDN LEKIGEAKVK LELEKEGINP EQTQKIIDFI 

       250        260        270        280        290        300 
KIDGSVDDVL DKLKHLSQTL PESEQFNLGV SELETVITGV RNLGVPDKRF CIDLAIARGL 

       310        320        330        340        350        360 
NYYTGTVYET TLIGHEALGS ICSGGRYEEL VGTFIGEKMP GVGISIGLTR LISRLLKAGI 

       370        380        390        400        410        420 
LNTLPPTPAQ VVVVNMQDNL MPTYLKVSQQ LRQAGLNVIT NFEKRQLGKQ FQAADKQGIQ 

       430        440        450        460 
FCVIIGADEA AAQKSSLKDL KSGEQVEVAL ADLPEEVKRR LT

« Hide

References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000117 Genomic DNA. Translation: ABA21878.1.
RefSeqYP_322773.1. NC_007413.1.

3D structure databases

ProteinModelPortalQ3MAV8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3MAV8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3679005.
GenomeReviewsGene locus Ava_2260 in contig CP000117_GR.
KEGGava:Ava_2260.
NMPDRfig|240292.3.peg.2527.
PATRIC35425309. VBIAnaVar43351_3205.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
HOGENOMHBG616575.
OMAIGKVFRD.
PhylomeDBQ3MAV8.
ProtClustDBPRK00037.

Enzyme and pathway databases

BioCycAVAR240292:AVA_2260-MONOMER.

Family and domain databases

HAMAPMF_00127. His_tRNA_synth.
[Tree]
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-synth_IIa_subgr.
IPR004516. His-tRNA_synth_IIA.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
KOK01892.
PANTHERPTHR11476. His-tRNA_synth. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. Anticodon_bd. 1 hit.
TIGRFAMsTIGR00442. HisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_ANAVT
AccessionPrimary (citable) accession number: Q3MAV8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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