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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei200UniRule annotation1
Active sitei251Proton donorUniRule annotation1
Active sitei321UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-5780-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:Ava_2321
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi
  • UP000002533 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000028611 – 331UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST331

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_2321

Structurei

3D structure databases

ProteinModelPortaliQ3MAP7
SMRiQ3MAP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 221FAD-binding PCMH-typeUniRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D4A Bacteria
COG0812 LUCA
HOGENOMiHOG000284355
KOiK00075
OMAiIGNAGSF
OrthoDBiPOG091H0270

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
TIGRFAMsiTIGR00179 murB, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q3MAP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISQAVGNA CTVPASNVET HNNNPSRESK IIYLPGTNCE IKSQALLSAF
60 70 80 90 100
TSYRVGGAAE LYVAPRNIEA LQASLKYAQE HNLRVTTLGA GSNLLVSDRG
110 120 130 140 150
ISGLVIATRH LRYNRFDHQT GQVTVAAGES IPSLAWEIAK LGWQGFEWAV
160 170 180 190 200
GIPGTVGGAV VMNAGAHNSC IADILVSAQV LSPDGTIETL TPEELGYGYR
210 220 230 240 250
TSLLQGSNRV VTQATFQLQP GFDPAYITAT TREHKQMRLT TQPYNFPSCG
260 270 280 290 300
SVFRNPKPYS AGWLIEQSGL KGYQIGGAQV AHLHANFIVN RGGAKANDIF
310 320 330
CLIRHIQQEV QERWSILLEP EVKMLGEFQA A
Length:331
Mass (Da):35,866
Last modified:October 25, 2005 - v1
Checksum:iDD170A1362E767AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA Translation: ABA21939.1

Genome annotation databases

EnsemblBacteriaiABA21939; ABA21939; Ava_2321
KEGGiava:Ava_2321

Similar proteinsi

Entry informationi

Entry nameiMURB_ANAVT
AccessioniPrimary (citable) accession number: Q3MAP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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