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Q3MAK0 (Q3MAK0_ANAVT) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
EC=3.6.1.19 HAMAP-Rule MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate diphosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP-Rule MF_01405
Gene names
Ordered Locus Names:Ava_2368 EMBL ABA21986.1
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP] EMBL ABA21986.1
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena ›

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405 SAAS SAAS020922

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP-Rule MF_01405 SAAS SAAS020922

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405 SAAS SAAS020922

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP-Rule MF_01405 RuleBase RU003781

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region9 – 146Substrate binding By similarity HAMAP-Rule MF_01405
Region68 – 692Substrate binding By similarity HAMAP-Rule MF_01405

Sites

Metal binding391Magnesium or manganese By similarity HAMAP-Rule MF_01405
Metal binding681Magnesium or manganese By similarity HAMAP-Rule MF_01405
Binding site1501Substrate By similarity HAMAP-Rule MF_01405
Binding site1701Substrate By similarity HAMAP-Rule MF_01405
Binding site1761Substrate By similarity HAMAP-Rule MF_01405

Sequences

Sequence LengthMass (Da)Tools
Q3MAK0 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: 15C8CF4D829CEA08

FASTA19620,985
        10         20         30         40         50         60 
MTKILVVATS NSGKLREMQA YLANTDWKLT LKPPELDVEE TGDTFAANAC LKASEVAKAT 

        70         80         90        100        110        120 
GNWAIADDSG LQVDALNGVP GVYSARYGKT DSERISRLLK ELDGEVNRKA QFVCVVAIAS 

       130        140        150        160        170        180 
PDGAITLQAE GICRGEILHA PRGSGGFGYD PIFYVTEKQL TFAEMTPELK KSVSHRGKAF 

       190 
AALLPKMATV LSSSSE

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References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000117 Genomic DNA. Translation: ABA21986.1.
RefSeqYP_322881.1. NC_007413.1.

3D structure databases

ProteinModelPortalQ3MAK0.
ModBaseSearch...

Protein-protein interaction databases

STRING240292.Ava_2368.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA21986; ABA21986; Ava_2368.
GeneID3683426.
KEGGava:Ava_2368.
PATRIC35425561. VBIAnaVar43351_3330.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHOG000293319.
KOK02428.
OMAGEAHNDA.
ProtClustDBPRK00120.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ3MAK0_ANAVT
AccessionPrimary (citable) accession number: Q3MAK0
Entry history
Integrated into UniProtKB/TrEMBL: October 25, 2005
Last sequence update: October 25, 2005
Last modified: May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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