Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3MAK0

- Q3MAK0_ANAVT

UniProt

Q3MAK0 - Q3MAK0_ANAVT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Non-canonical purine NTP pyrophosphatase

Gene

Ava_2368

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391Magnesium or manganeseUniRule annotation
Metal bindingi68 – 681Magnesium or manganeseUniRule annotation
Binding sitei150 – 1501SubstrateUniRule annotation
Binding sitei170 – 1701SubstrateUniRule annotation
Binding sitei176 – 1761SubstrateUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Nucleotide metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-2396-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphataseUniRule annotationSAAS annotation (EC:3.6.1.19UniRule annotationSAAS annotation)
Alternative name(s):
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Gene namesi
Ordered Locus Names:Ava_2368Imported
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)Imported
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi240292.Ava_2368.

Structurei

3D structure databases

ProteinModelPortaliQ3MAK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 146Substrate bindingUniRule annotation
Regioni68 – 692Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0127.
HOGENOMiHOG000293319.
KOiK02428.
OMAiMELFLEW.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3MAK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKILVVATS NSGKLREMQA YLANTDWKLT LKPPELDVEE TGDTFAANAC
60 70 80 90 100
LKASEVAKAT GNWAIADDSG LQVDALNGVP GVYSARYGKT DSERISRLLK
110 120 130 140 150
ELDGEVNRKA QFVCVVAIAS PDGAITLQAE GICRGEILHA PRGSGGFGYD
160 170 180 190
PIFYVTEKQL TFAEMTPELK KSVSHRGKAF AALLPKMATV LSSSSE
Length:196
Mass (Da):20,985
Last modified:October 25, 2005 - v1
Checksum:i15C8CF4D829CEA08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA21986.1.
RefSeqiWP_011319152.1. NC_007413.1.
YP_322881.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA21986; ABA21986; Ava_2368.
GeneIDi3683426.
KEGGiava:Ava_2368.
PATRICi35425561. VBIAnaVar43351_3330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA21986.1 .
RefSeqi WP_011319152.1. NC_007413.1.
YP_322881.1. NC_007413.1.

3D structure databases

ProteinModelPortali Q3MAK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240292.Ava_2368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA21986 ; ABA21986 ; Ava_2368 .
GeneIDi 3683426.
KEGGi ava:Ava_2368.
PATRICi 35425561. VBIAnaVar43351_3330.

Phylogenomic databases

eggNOGi COG0127.
HOGENOMi HOG000293319.
KOi K02428.
OMAi MELFLEW.
OrthoDBi EOG6CZQQP.

Enzyme and pathway databases

BioCyci AVAR240292:GCY3-2396-MONOMER.

Family and domain databases

Gene3Di 3.90.950.10. 1 hit.
HAMAPi MF_01405. Non_canon_purine_NTPase.
InterProi IPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937Imported.

Entry informationi

Entry nameiQ3MAK0_ANAVT
AccessioniPrimary (citable) accession number: Q3MAK0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2005
Last sequence update: October 25, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3