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Q3MAK0

- Q3MAK0_ANAVT

UniProt

Q3MAK0 - Q3MAK0_ANAVT

Protein

Non-canonical purine NTP pyrophosphatase

Gene

Ava_2368

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

    Catalytic activityi

    A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi39 – 391Magnesium or manganeseUniRule annotation
    Metal bindingi68 – 681Magnesium or manganeseUniRule annotation
    Binding sitei150 – 1501SubstrateUniRule annotation
    Binding sitei170 – 1701SubstrateUniRule annotation
    Binding sitei176 – 1761SubstrateUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro
    3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleoside triphosphate catabolic process Source: InterPro
    2. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Nucleotide metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciAVAR240292:GCY3-2396-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
    Alternative name(s):
    Non-standard purine NTP pyrophosphataseUniRule annotation
    Nucleoside-triphosphate diphosphataseUniRule annotation
    Nucleoside-triphosphate pyrophosphataseUniRule annotation
    Gene namesi
    Ordered Locus Names:Ava_2368Imported
    OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)Imported
    Taxonomic identifieri240292 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
    ProteomesiUP000002533: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi240292.Ava_2368.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MAK0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni9 – 146Substrate bindingUniRule annotation
    Regioni68 – 692Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the HAM1 NTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0127.
    HOGENOMiHOG000293319.
    KOiK02428.
    OMAiMELFLEW.
    OrthoDBiEOG6CZQQP.

    Family and domain databases

    Gene3Di3.90.950.10. 1 hit.
    HAMAPiMF_01405. Non_canon_purine_NTPase.
    InterProiIPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view]
    PANTHERiPTHR11067. PTHR11067. 1 hit.
    PfamiPF01725. Ham1p_like. 1 hit.
    [Graphical view]
    SUPFAMiSSF52972. SSF52972. 1 hit.
    TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3MAK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKILVVATS NSGKLREMQA YLANTDWKLT LKPPELDVEE TGDTFAANAC    50
    LKASEVAKAT GNWAIADDSG LQVDALNGVP GVYSARYGKT DSERISRLLK 100
    ELDGEVNRKA QFVCVVAIAS PDGAITLQAE GICRGEILHA PRGSGGFGYD 150
    PIFYVTEKQL TFAEMTPELK KSVSHRGKAF AALLPKMATV LSSSSE 196
    Length:196
    Mass (Da):20,985
    Last modified:October 25, 2005 - v1
    Checksum:i15C8CF4D829CEA08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000117 Genomic DNA. Translation: ABA21986.1.
    RefSeqiYP_322881.1. NC_007413.1.

    Genome annotation databases

    EnsemblBacteriaiABA21986; ABA21986; Ava_2368.
    GeneIDi3683426.
    KEGGiava:Ava_2368.
    PATRICi35425561. VBIAnaVar43351_3330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000117 Genomic DNA. Translation: ABA21986.1 .
    RefSeqi YP_322881.1. NC_007413.1.

    3D structure databases

    ProteinModelPortali Q3MAK0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 240292.Ava_2368.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA21986 ; ABA21986 ; Ava_2368 .
    GeneIDi 3683426.
    KEGGi ava:Ava_2368.
    PATRICi 35425561. VBIAnaVar43351_3330.

    Phylogenomic databases

    eggNOGi COG0127.
    HOGENOMi HOG000293319.
    KOi K02428.
    OMAi MELFLEW.
    OrthoDBi EOG6CZQQP.

    Enzyme and pathway databases

    BioCyci AVAR240292:GCY3-2396-MONOMER.

    Family and domain databases

    Gene3Di 3.90.950.10. 1 hit.
    HAMAPi MF_01405. Non_canon_purine_NTPase.
    InterProi IPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view ]
    PANTHERi PTHR11067. PTHR11067. 1 hit.
    Pfami PF01725. Ham1p_like. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52972. SSF52972. 1 hit.
    TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Anabaena variabilis ATCC 29413."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29413 / PCC 7937Imported.

    Entry informationi

    Entry nameiQ3MAK0_ANAVT
    AccessioniPrimary (citable) accession number: Q3MAK0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 25, 2005
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3