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Q3MAF5 (ISPD_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
EC=2.7.7.60
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase
MEP cytidylyltransferase
Short name=MCT
Gene names
Name:ispD
Ordered Locus Names:Ava_2414
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108

Sequence similarities

Belongs to the IspD family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2282282-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
PRO_0000237768

Sites

Site131Transition state stabilizer By similarity
Site201Transition state stabilizer By similarity
Site1521Positions MEP for the nucleophilic attack By similarity
Site2081Positions MEP for the nucleophilic attack By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3MAF5 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: 5C5E43365179F7FF

FASTA22824,854
        10         20         30         40         50         60 
MYLLIPAAGV GKRMGCDRNK LLLEVRSQPI IAWTLLAAQA ASEISWIGII SQPTDWPDFK 

        70         80         90        100        110        120 
SILANLQLTK PVEFILGGST RQESVYNGLQ ALPKAAEQVL IHDGARCLAT PNLLNSCAQA 

       130        140        150        160        170        180 
IRHCSGLIAA VPVKDTIKVA DEDGIIQSTP DRRNLWAAQT PQGFNVELLK QCHAEGVRQG 

       190        200        210        220 
WEVTDDAALF EKCGIEVQIV EGEETNLKVT TPQDLAIAEF ILNSRDNS

« Hide

References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000117 Genomic DNA. Translation: ABA22031.1.
RefSeqYP_322926.1. NC_007413.1.

3D structure databases

ProteinModelPortalQ3MAF5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3MAF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3683096.
GenomeReviewsGene locus Ava_2414 in contig CP000117_GR.
KEGGava:Ava_2414.
NMPDRfig|240292.3.peg.1353.
PATRIC35425665. VBIAnaVar43351_3382.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1211.
HOGENOMHBG672839.
OMASKVIVVC.
PhylomeDBQ3MAF5.
ProtClustDBPRK00155.

Enzyme and pathway databases

BioCycAVAR240292:AVA_2414-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00453. IspD. 1 hit.
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPD_ANAVT
AccessionPrimary (citable) accession number: Q3MAF5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 25, 2005
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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