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Protein

Isopentenyl-diphosphate delta-isomerase

Gene

fni

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).UniRule annotation

Catalytic activityi

Isopentenyl diphosphate = dimethylallyl diphosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FMNUniRule annotation
  • NADPHUniRule annotation
  • Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73FMNUniRule annotation1
Binding sitei104FMN; via amide nitrogenUniRule annotation1
Binding sitei132FMNUniRule annotation1
Binding sitei167SubstrateUniRule annotation1
Metal bindingi168MagnesiumUniRule annotation1
Binding sitei199FMNUniRule annotation1
Binding sitei229FMN; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 76FMNUniRule annotation3
Nucleotide bindingi279 – 281FMNUniRule annotation3
Nucleotide bindingi300 – 301FMNUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Flavoprotein, FMN, Magnesium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-6115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isopentenyl-diphosphate delta-isomeraseUniRule annotation (EC:5.3.3.2UniRule annotation)
Short name:
IPP isomeraseUniRule annotation
Alternative name(s):
Isopentenyl diphosphate:dimethylallyl diphosphate isomeraseUniRule annotation
Isopentenyl pyrophosphate isomeraseUniRule annotation
Type 2 isopentenyl diphosphate isomeraseUniRule annotation
Short name:
IDI-2UniRule annotation
Gene namesi
Name:fniUniRule annotation
Ordered Locus Names:Ava_2461
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
Proteomesi
  • UP000002533 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002294931 – 350Isopentenyl-diphosphate delta-isomeraseAdd BLAST350

Interactioni

Subunit structurei

Homooctamer. Dimer of tetramers.UniRule annotation

Protein-protein interaction databases

STRINGi240292.Ava_2461.

Structurei

3D structure databases

ProteinModelPortaliQ3MAB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 16Substrate bindingUniRule annotation2
Regioni104 – 106Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the IPP isomerase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106UJV. Bacteria.
COG1304. LUCA.
HOGENOMiHOG000072126.
KOiK01823.
OMAiGSQRVML.
OrthoDBiPOG091H07K8.

Family and domain databases

CDDicd02811. IDI-2_FMN. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00354. Idi_2. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR011179. IPdP_isomerase.
[Graphical view]
PANTHERiPTHR10578:SF3. PTHR10578:SF3. 2 hits.
PfamiPF01070. FMN_dh. 2 hits.
[Graphical view]
PIRSFiPIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMsiTIGR02151. IPP_isom_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3MAB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPATSNSA QTQSRKADHI RICLEEDVQF RATTNGLERY RFNHSCLPEI
60 70 80 90 100
DRNDIDLSAT FLGKKLNAPL LISSMTGGTE QAGIINQRLA RLAQDYKFAM
110 120 130 140 150
GVGSQRVALE KPQVADTFAI RKYAPDVLLF ANVGAVQLNY KYGLDECLRI
160 170 180 190 200
IDMLEADALI LHINPLQECI QPKGDVNFQG LLDKISELCE ELSVPVIAKE
210 220 230 240 250
VGNGISGAMA KKLIAAGVQV IDVAGAGGTS WAKVEGERAE NSMQRRLGRT
260 270 280 290 300
FADWGIPTAE CITSVRAIAP HIPLIASGGL RDGLDIAKAI ALGADIAGLA
310 320 330 340 350
MPFLQAAVES EAALQELAEV LIAEITTVLF CTGNATLHQL KHSGSLQRLQ
Length:350
Mass (Da):37,631
Last modified:October 25, 2005 - v1
Checksum:iA6F6C859839DF334
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA22076.1.

Genome annotation databases

EnsemblBacteriaiABA22076; ABA22076; Ava_2461.
KEGGiava:Ava_2461.
PATRICi35425769. VBIAnaVar43351_3434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA22076.1.

3D structure databases

ProteinModelPortaliQ3MAB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi240292.Ava_2461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA22076; ABA22076; Ava_2461.
KEGGiava:Ava_2461.
PATRICi35425769. VBIAnaVar43351_3434.

Phylogenomic databases

eggNOGiENOG4106UJV. Bacteria.
COG1304. LUCA.
HOGENOMiHOG000072126.
KOiK01823.
OMAiGSQRVML.
OrthoDBiPOG091H07K8.

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-6115-MONOMER.

Family and domain databases

CDDicd02811. IDI-2_FMN. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00354. Idi_2. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR011179. IPdP_isomerase.
[Graphical view]
PANTHERiPTHR10578:SF3. PTHR10578:SF3. 2 hits.
PfamiPF01070. FMN_dh. 2 hits.
[Graphical view]
PIRSFiPIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMsiTIGR02151. IPP_isom_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIDI2_ANAVT
AccessioniPrimary (citable) accession number: Q3MAB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2005
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.