Reviewed, UniProtKB/Swiss-Prot Q3MAA1 (APT_ANAVT)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase
      Short name=APRT
    EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	Ava_2470

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Adenine phosphoribosyltransferase HAMAP MF_00004		PRO_1000000254

Sequences

	Sequence		Length	Mass (Da)
	Q3MAA1-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: A58B02C45ECE6AEC	FASTA	172	19,205
	10 20 30 40 50 60 MDLKSLIRDI PDFPKPGILF RDITTLLRDR QGLRYTIDFL AEKCFEANLD IDYVIGMESR 70 80 90 100 110 120 GFIFGTPLAY KLGAGFIPVR KKGKLPAAVH SIEYELEYGT DCLEVHRDAL HPDSRVLIVD 130 140 150 160 170 DLIATGGTAS ATAKLVQQIG CELVGFGFII ELRDLQGRKH LPDVPIISLV EY

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA22085.1.
RefSeq	YP_322980.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MAA1.
Genome annotation databases
GeneID	3682821.
GenomeReviews	Gene locus Ava_2470 in contig CP000117_GR.
KEGG	ava:Ava_2470.
NMPDR	fig|240292.3.peg.1527.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3MAA1.
OMA	KPGKLPA.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_2470-MON.
Family and domain databases
HAMAP	MF_00004. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_ANAVT

Accession

Primary (citable) accession number: Q3MAA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2005
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)