ID   RNPH_ANAVT              Reviewed;         247 AA.
AC   Q3M9Q2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Ribonuclease PH;
DE            Short=RNase PH;
DE            EC=2.7.7.56;
DE   AltName: Full=tRNA nucleotidyltransferase;
GN   Name=rph; OrderedLocusNames=Ava_2671;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phosphorolytic exoribonuclease that removes nucleotide
CC       residues following the -CCA terminus of tRNA and adds nucleotides
CC       to the ends of RNA molecules by using nucleoside diphosphates as
CC       substrates (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside
CC       diphosphate.
CC   -!- SIMILARITY: Belongs to the RNase PH family.
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DR   EMBL; CP000117; ABA22284.1; -; Genomic_DNA.
DR   RefSeq; YP_323179.1; -.
DR   GeneID; 3682032; -.
DR   GenomeReviews; CP000117_GR; Ava_2671.
DR   KEGG; ava:Ava_2671; -.
DR   NMPDR; fig|240292.3.peg.945; -.
DR   HOGENOM; Q3M9Q2; -.
DR   OMA; Q3M9Q2; YAMLPRA.
DR   BioCyc; AVAR240292:AVA_2671-MON; -.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:HAMAP.
DR   GO; GO:0009022; F:tRNA nucleotidyltransferase activity; IEA:HAMAP.
DR   GO; GO:0004549; F:tRNA-specific ribonuclease activity; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:HAMAP.
DR   HAMAP; MF_00564; -; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR018336; Ribonuclease-PH_CS.
DR   InterPro; IPR002381; RNase_PH_bac-type.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   TIGRFAMs; TIGR01966; RNasePH; 1.
DR   PROSITE; PS01277; RIBONUCLEASE_PH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Nucleotidyltransferase; Transferase;
KW   tRNA processing.
FT   CHAIN         1    247       Ribonuclease PH.
FT                                /FTId=PRO_1000024773.
SQ   SEQUENCE   247 AA;  27081 MW;  0C90C04AB939A629 CRC64;
     MVWQRPDGRK PYELRPINFH TKFTRFAPGS VLTICGETKV LCTVSVAESV PKFLAGSGKG
     WLTAEYRMLP SATQQRHERE LLKLSGRTQE IQRLIGRSLR AAIDFEALGE RTLTVDADVL
     QADAGTRTAA ITGGFVALAE AISQLLQRGV LERSPLCGQV AAVSVGLLEQ EAYLDLNYIE
     DVAATVDFNV VMNKNLGIIE VQGTAEEGSF SRTQLNQLLD CAETGIQQLL IAQQKAITDW
     DELFVGK
//