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Protein

NAD kinase 2

Gene

nadK2

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Proton acceptorUniRule annotation1
Binding sitei160NADUniRule annotation1
Binding sitei181NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 68NADUniRule annotation2
Nucleotide bindingi149 – 150NADUniRule annotation2
Nucleotide bindingi192 – 197NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-6576-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:Ava_2718
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi
  • UP000002533 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002295971 – 306NAD kinase 2Add BLAST306

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_2718

Structurei

3D structure databases

ProteinModelPortaliQ3M9K5
SMRiQ3M9K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiHLGFLTH
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q3M9K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLKQVIIAY KARDSQSKRW AELCAKQLEN RNCQVLMGPS GPKDNPYPVF
60 70 80 90 100
LASASQPIDL AIVLGGDGTV LTSARHLAPA GIPILGVNVG GHLGFLTESV
110 120 130 140 150
DEFQDTEKVW DRLFEDRYAI QRRMMLQAAV YEGHRTNLEP VTERYLGLNE
160 170 180 190 200
FCVKPASADR MITSILEMEI DGEVVDQYVG DGLIISTPTG STGYTVSASG
210 220 230 240 250
PIMHDGMEAI TITPICPMSL SSRPLILPAG SVVSIWPLGD YDLSTKLWMD
260 270 280 290 300
GVLATSIWPA HRVDIRMADC RAKFIVLREN NSYYQTLREK LLWAGTRVRY

TSTQHN
Length:306
Mass (Da):33,933
Last modified:October 25, 2005 - v1
Checksum:i92FF532C5F3D15A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA Translation: ABA22331.1
RefSeqiWP_010994404.1, NC_007413.1

Genome annotation databases

EnsemblBacteriaiABA22331; ABA22331; Ava_2718
KEGGiava:Ava_2718

Similar proteinsi

Entry informationi

Entry nameiNADK2_ANAVT
AccessioniPrimary (citable) accession number: Q3M9K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2005
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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