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Q3M9K5

- NADK2_ANAVT

UniProt

Q3M9K5 - NADK2_ANAVT

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Protein

NAD kinase 2

Gene
nadK2, Ava_2718
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptor By similarity
Binding sitei160 – 1601NAD By similarity
Binding sitei181 – 1811NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NAD By similarity
Nucleotide bindingi149 – 1502NAD By similarity
Nucleotide bindingi192 – 1976NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-2751-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 2
Gene namesi
Name:nadK2
Ordered Locus Names:Ava_2718
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306NAD kinase 2UniRule annotationPRO_0000229597Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_2718.

Structurei

3D structure databases

ProteinModelPortaliQ3M9K5.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiKLHWAGS.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3M9K5-1 [UniParc]FASTAAdd to Basket

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MQLKQVIIAY KARDSQSKRW AELCAKQLEN RNCQVLMGPS GPKDNPYPVF    50
LASASQPIDL AIVLGGDGTV LTSARHLAPA GIPILGVNVG GHLGFLTESV 100
DEFQDTEKVW DRLFEDRYAI QRRMMLQAAV YEGHRTNLEP VTERYLGLNE 150
FCVKPASADR MITSILEMEI DGEVVDQYVG DGLIISTPTG STGYTVSASG 200
PIMHDGMEAI TITPICPMSL SSRPLILPAG SVVSIWPLGD YDLSTKLWMD 250
GVLATSIWPA HRVDIRMADC RAKFIVLREN NSYYQTLREK LLWAGTRVRY 300
TSTQHN 306
Length:306
Mass (Da):33,933
Last modified:October 25, 2005 - v1
Checksum:i92FF532C5F3D15A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA22331.1.
RefSeqiYP_323226.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA22331; ABA22331; Ava_2718.
GeneIDi3682079.
KEGGiava:Ava_2718.
PATRICi35426331. VBIAnaVar43351_3711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA22331.1 .
RefSeqi YP_323226.1. NC_007413.1.

3D structure databases

ProteinModelPortali Q3M9K5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240292.Ava_2718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA22331 ; ABA22331 ; Ava_2718 .
GeneIDi 3682079.
KEGGi ava:Ava_2718.
PATRICi 35426331. VBIAnaVar43351_3711.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi KLHWAGS.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci AVAR240292:GCY3-2751-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiNADK2_ANAVT
AccessioniPrimary (citable) accession number: Q3M9K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2005
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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