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Q3M9G1

- GCSP_ANAVT

UniProt

Q3M9G1 - GCSP_ANAVT

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciAVAR240292:GCY3-2796-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Ava_2762
    OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
    Taxonomic identifieri240292 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
    ProteomesiUP000002533: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 974974Glycine dehydrogenase (decarboxylating)PRO_1000045565Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei722 – 7221N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi240292.Ava_2762.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3M9G1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3M9G1-1 [UniParc]FASTAAdd to Basket

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    MVSYASIRQS SDEADSTVDA SQKLDARKQD LNNFIQRHIG PSSADIQHML    50
    DVLGFSSLDD LIEKTVPSTI RLHKKLQLPT AQTEYAALAK LKQIASKNQV 100
    FRSYIGMGYY DTITPPVIGR NILENPGWYT AYTPYQPEIA QGRLEALLNF 150
    QTMIIDLTGL EIANASLLDE ATAAAEAMSM SYGVSKNKAN AYFVSHDCHP 200
    QTIDVLQTRA KPLGIEIIIG DHQTFDFQKP IFGAVLQYPA SDGTIYDYRA 250
    FIETAHAQGA LVTVAADPLS LTLLTPPGEF GADIAVGSTQ RFGIPLGFGG 300
    PHAAYFATKE EYKRQVPGRI VGVSKDVNGK TALRLALQTR EQHIRREKAT 350
    SNICTAQVLL AVMASMYAVY HGPEGLKQIA ENIHQLTVTL AEGLKRLGYK 400
    ISSEHFFDTL RVELGTNNLE TILAGCQARN INLRIFDETA VGISLDETTT 450
    PEDLIDLWQI FAGEDNLPFT PEELISSLNL PLRSSSYLTH PVFNRYHSET 500
    ELLRYLHRLE TKDLSLTTSM IPLGSCTMKL NATSEMIPVT WEEFGRIHPF 550
    APLTQTRGYQ ILFQQLEAWL AEITGFAGVA LQPNAGSQGE YTGLLVIRQY 600
    HESRGETHRN VCLIPTSAHG TNPASAVMCG MKVVAVACDA GGNIDIDDLK 650
    AKAEKHSHEL AALMVTYPST HGVFEAGIQE ICAVIHSHGG QVYMDGANMN 700
    AQVGICRPGD IGADVCHLNL HKTFCIPHGG GGPGMGPIGV ASHLVRFLPG 750
    HPVLGSGKNP QNIGAVAAAP WGSASILVIS WMYIAMMGAD GLTQATKVAI 800
    LNANYIAKRL ETYYPVLYKG QNGLVAHECI LDLRALKKSA NIEIDDIAKR 850
    LIDYGFHAPT VSWPVTGTIM VEPTESESQA ELDRFCDALI AIRQEIAAIE 900
    AGKMDTHNNL LKNAPHTIES LIVGEWLHPY SREQAAYPVS WTREYKFWPS 950
    VGRIDAAFGD RNFVCSCLPM EAYN 974
    Length:974
    Mass (Da):106,624
    Last modified:October 25, 2005 - v1
    Checksum:i2BA5DCABC5F1E5C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000117 Genomic DNA. Translation: ABA22375.1.
    RefSeqiWP_011319516.1. NC_007413.1.
    YP_323270.1. NC_007413.1.

    Genome annotation databases

    EnsemblBacteriaiABA22375; ABA22375; Ava_2762.
    GeneIDi3681890.
    KEGGiava:Ava_2762.
    PATRICi35426431. VBIAnaVar43351_3760.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000117 Genomic DNA. Translation: ABA22375.1 .
    RefSeqi WP_011319516.1. NC_007413.1.
    YP_323270.1. NC_007413.1.

    3D structure databases

    ProteinModelPortali Q3M9G1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 240292.Ava_2762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA22375 ; ABA22375 ; Ava_2762 .
    GeneIDi 3681890.
    KEGGi ava:Ava_2762.
    PATRICi 35426431. VBIAnaVar43351_3760.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci AVAR240292:GCY3-2796-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Anabaena variabilis ATCC 29413."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29413 / PCC 7937.

    Entry informationi

    Entry nameiGCSP_ANAVT
    AccessioniPrimary (citable) accession number: Q3M9G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3