SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3M9G1

- GCSP_ANAVT

UniProt

Q3M9G1 - GCSP_ANAVT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Ava_2762
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-2796-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Ava_2762
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei722 – 7221N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi240292.Ava_2762.

Structurei

3D structure databases

ProteinModelPortaliQ3M9G1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3M9G1-1 [UniParc]FASTAAdd to Basket

« Hide

MVSYASIRQS SDEADSTVDA SQKLDARKQD LNNFIQRHIG PSSADIQHML    50
DVLGFSSLDD LIEKTVPSTI RLHKKLQLPT AQTEYAALAK LKQIASKNQV 100
FRSYIGMGYY DTITPPVIGR NILENPGWYT AYTPYQPEIA QGRLEALLNF 150
QTMIIDLTGL EIANASLLDE ATAAAEAMSM SYGVSKNKAN AYFVSHDCHP 200
QTIDVLQTRA KPLGIEIIIG DHQTFDFQKP IFGAVLQYPA SDGTIYDYRA 250
FIETAHAQGA LVTVAADPLS LTLLTPPGEF GADIAVGSTQ RFGIPLGFGG 300
PHAAYFATKE EYKRQVPGRI VGVSKDVNGK TALRLALQTR EQHIRREKAT 350
SNICTAQVLL AVMASMYAVY HGPEGLKQIA ENIHQLTVTL AEGLKRLGYK 400
ISSEHFFDTL RVELGTNNLE TILAGCQARN INLRIFDETA VGISLDETTT 450
PEDLIDLWQI FAGEDNLPFT PEELISSLNL PLRSSSYLTH PVFNRYHSET 500
ELLRYLHRLE TKDLSLTTSM IPLGSCTMKL NATSEMIPVT WEEFGRIHPF 550
APLTQTRGYQ ILFQQLEAWL AEITGFAGVA LQPNAGSQGE YTGLLVIRQY 600
HESRGETHRN VCLIPTSAHG TNPASAVMCG MKVVAVACDA GGNIDIDDLK 650
AKAEKHSHEL AALMVTYPST HGVFEAGIQE ICAVIHSHGG QVYMDGANMN 700
AQVGICRPGD IGADVCHLNL HKTFCIPHGG GGPGMGPIGV ASHLVRFLPG 750
HPVLGSGKNP QNIGAVAAAP WGSASILVIS WMYIAMMGAD GLTQATKVAI 800
LNANYIAKRL ETYYPVLYKG QNGLVAHECI LDLRALKKSA NIEIDDIAKR 850
LIDYGFHAPT VSWPVTGTIM VEPTESESQA ELDRFCDALI AIRQEIAAIE 900
AGKMDTHNNL LKNAPHTIES LIVGEWLHPY SREQAAYPVS WTREYKFWPS 950
VGRIDAAFGD RNFVCSCLPM EAYN 974
Length:974
Mass (Da):106,624
Last modified:October 25, 2005 - v1
Checksum:i2BA5DCABC5F1E5C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA22375.1.
RefSeqiWP_011319516.1. NC_007413.1.
YP_323270.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA22375; ABA22375; Ava_2762.
GeneIDi3681890.
KEGGiava:Ava_2762.
PATRICi35426431. VBIAnaVar43351_3760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA22375.1 .
RefSeqi WP_011319516.1. NC_007413.1.
YP_323270.1. NC_007413.1.

3D structure databases

ProteinModelPortali Q3M9G1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 240292.Ava_2762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA22375 ; ABA22375 ; Ava_2762 .
GeneIDi 3681890.
KEGGi ava:Ava_2762.
PATRICi 35426431. VBIAnaVar43351_3760.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AVAR240292:GCY3-2796-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiGCSP_ANAVT
AccessioniPrimary (citable) accession number: Q3M9G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi