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Q3M9G1 (GCSP_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Ava_2762
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena

Protein attributes

Sequence length974 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 974974Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045565

Amino acid modifications

Modified residue7221N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3M9G1 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: 2BA5DCABC5F1E5C9

FASTA974106,624
        10         20         30         40         50         60 
MVSYASIRQS SDEADSTVDA SQKLDARKQD LNNFIQRHIG PSSADIQHML DVLGFSSLDD 

        70         80         90        100        110        120 
LIEKTVPSTI RLHKKLQLPT AQTEYAALAK LKQIASKNQV FRSYIGMGYY DTITPPVIGR 

       130        140        150        160        170        180 
NILENPGWYT AYTPYQPEIA QGRLEALLNF QTMIIDLTGL EIANASLLDE ATAAAEAMSM 

       190        200        210        220        230        240 
SYGVSKNKAN AYFVSHDCHP QTIDVLQTRA KPLGIEIIIG DHQTFDFQKP IFGAVLQYPA 

       250        260        270        280        290        300 
SDGTIYDYRA FIETAHAQGA LVTVAADPLS LTLLTPPGEF GADIAVGSTQ RFGIPLGFGG 

       310        320        330        340        350        360 
PHAAYFATKE EYKRQVPGRI VGVSKDVNGK TALRLALQTR EQHIRREKAT SNICTAQVLL 

       370        380        390        400        410        420 
AVMASMYAVY HGPEGLKQIA ENIHQLTVTL AEGLKRLGYK ISSEHFFDTL RVELGTNNLE 

       430        440        450        460        470        480 
TILAGCQARN INLRIFDETA VGISLDETTT PEDLIDLWQI FAGEDNLPFT PEELISSLNL 

       490        500        510        520        530        540 
PLRSSSYLTH PVFNRYHSET ELLRYLHRLE TKDLSLTTSM IPLGSCTMKL NATSEMIPVT 

       550        560        570        580        590        600 
WEEFGRIHPF APLTQTRGYQ ILFQQLEAWL AEITGFAGVA LQPNAGSQGE YTGLLVIRQY 

       610        620        630        640        650        660 
HESRGETHRN VCLIPTSAHG TNPASAVMCG MKVVAVACDA GGNIDIDDLK AKAEKHSHEL 

       670        680        690        700        710        720 
AALMVTYPST HGVFEAGIQE ICAVIHSHGG QVYMDGANMN AQVGICRPGD IGADVCHLNL 

       730        740        750        760        770        780 
HKTFCIPHGG GGPGMGPIGV ASHLVRFLPG HPVLGSGKNP QNIGAVAAAP WGSASILVIS 

       790        800        810        820        830        840 
WMYIAMMGAD GLTQATKVAI LNANYIAKRL ETYYPVLYKG QNGLVAHECI LDLRALKKSA 

       850        860        870        880        890        900 
NIEIDDIAKR LIDYGFHAPT VSWPVTGTIM VEPTESESQA ELDRFCDALI AIRQEIAAIE 

       910        920        930        940        950        960 
AGKMDTHNNL LKNAPHTIES LIVGEWLHPY SREQAAYPVS WTREYKFWPS VGRIDAAFGD 

       970 
RNFVCSCLPM EAYN 

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References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000117 Genomic DNA. Translation: ABA22375.1.
RefSeqYP_323270.1. NC_007413.1.

3D structure databases

ProteinModelPortalQ3M9G1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING240292.Ava_2762.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA22375; ABA22375; Ava_2762.
GeneID3681890.
KEGGava:Ava_2762.
PATRIC35426431. VBIAnaVar43351_3760.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycAVAR240292:GCY3-2796-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_ANAVT
AccessionPrimary (citable) accession number: Q3M9G1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families