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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-6620-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Ava_2762
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi
  • UP000002533 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000455651 – 974Glycine dehydrogenase (decarboxylating)Add BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei722N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ3M9G1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi240292.Ava_2762

Structurei

3D structure databases

ProteinModelPortaliQ3M9G1
SMRiQ3M9G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q3M9G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSYASIRQS SDEADSTVDA SQKLDARKQD LNNFIQRHIG PSSADIQHML
60 70 80 90 100
DVLGFSSLDD LIEKTVPSTI RLHKKLQLPT AQTEYAALAK LKQIASKNQV
110 120 130 140 150
FRSYIGMGYY DTITPPVIGR NILENPGWYT AYTPYQPEIA QGRLEALLNF
160 170 180 190 200
QTMIIDLTGL EIANASLLDE ATAAAEAMSM SYGVSKNKAN AYFVSHDCHP
210 220 230 240 250
QTIDVLQTRA KPLGIEIIIG DHQTFDFQKP IFGAVLQYPA SDGTIYDYRA
260 270 280 290 300
FIETAHAQGA LVTVAADPLS LTLLTPPGEF GADIAVGSTQ RFGIPLGFGG
310 320 330 340 350
PHAAYFATKE EYKRQVPGRI VGVSKDVNGK TALRLALQTR EQHIRREKAT
360 370 380 390 400
SNICTAQVLL AVMASMYAVY HGPEGLKQIA ENIHQLTVTL AEGLKRLGYK
410 420 430 440 450
ISSEHFFDTL RVELGTNNLE TILAGCQARN INLRIFDETA VGISLDETTT
460 470 480 490 500
PEDLIDLWQI FAGEDNLPFT PEELISSLNL PLRSSSYLTH PVFNRYHSET
510 520 530 540 550
ELLRYLHRLE TKDLSLTTSM IPLGSCTMKL NATSEMIPVT WEEFGRIHPF
560 570 580 590 600
APLTQTRGYQ ILFQQLEAWL AEITGFAGVA LQPNAGSQGE YTGLLVIRQY
610 620 630 640 650
HESRGETHRN VCLIPTSAHG TNPASAVMCG MKVVAVACDA GGNIDIDDLK
660 670 680 690 700
AKAEKHSHEL AALMVTYPST HGVFEAGIQE ICAVIHSHGG QVYMDGANMN
710 720 730 740 750
AQVGICRPGD IGADVCHLNL HKTFCIPHGG GGPGMGPIGV ASHLVRFLPG
760 770 780 790 800
HPVLGSGKNP QNIGAVAAAP WGSASILVIS WMYIAMMGAD GLTQATKVAI
810 820 830 840 850
LNANYIAKRL ETYYPVLYKG QNGLVAHECI LDLRALKKSA NIEIDDIAKR
860 870 880 890 900
LIDYGFHAPT VSWPVTGTIM VEPTESESQA ELDRFCDALI AIRQEIAAIE
910 920 930 940 950
AGKMDTHNNL LKNAPHTIES LIVGEWLHPY SREQAAYPVS WTREYKFWPS
960 970
VGRIDAAFGD RNFVCSCLPM EAYN
Length:974
Mass (Da):106,624
Last modified:October 25, 2005 - v1
Checksum:i2BA5DCABC5F1E5C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA Translation: ABA22375.1

Genome annotation databases

EnsemblBacteriaiABA22375; ABA22375; Ava_2762
KEGGiava:Ava_2762

Similar proteinsi

Entry informationi

Entry nameiGCSP_ANAVT
AccessioniPrimary (citable) accession number: Q3M9G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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