ID   KHSE_ANAVT              Reviewed;         302 AA.
AC   Q3M9C9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Homoserine kinase;
DE            Short=HSK;
DE            Short=HK;
DE            EC=2.7.1.39;
GN   Name=thrB; OrderedLocusNames=Ava_2794;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC       subfamily.
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DR   EMBL; CP000117; ABA22407.1; -; Genomic_DNA.
DR   RefSeq; YP_323302.1; -.
DR   GeneID; 3681630; -.
DR   GenomeReviews; CP000117_GR; Ava_2794.
DR   KEGG; ava:Ava_2794; -.
DR   NMPDR; fig|240292.3.peg.1374; -.
DR   HOGENOM; Q3M9C9; -.
DR   OMA; Q3M9C9; FDCLGAA.
DR   BioCyc; AVAR240292:AVA_2794-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR   GO; GO:0016310; P:phosphorylation; IEA:InterPro.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00384; -; 1.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd_CS.
DR   InterPro; IPR000870; Homoserine_kin.
DR   InterPro; IPR014721; Ribosomal_S5_D2-type_fold.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000676; Homoser_kin; 1.
DR   PRINTS; PR00958; HOMSERKINASE.
DR   TIGRFAMs; TIGR00191; thrB; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
FT   CHAIN         1    302       Homoserine kinase.
FT                                /FTId=PRO_1000049106.
FT   NP_BIND      92    102       ATP (Potential).
SQ   SEQUENCE   302 AA;  31492 MW;  1388FF5076BC99D2 CRC64;
     MSVVSSVTVK VPGTTANLGP GFDCIGAALT IYNQFQFTRL ETSELIIQAT GAEAERVPTD
     ESNLLYQAFV KLYQYIDQTP PGVKVEIELG VPLARGLGSS ATAIVGGLVA ANRLAGEPLS
     QAQVMELAIA IEGHPDNVVP ALVGGCRLAA TGAMGWEICD VPWHGDIVPV LAIPDFELST
     SEARRVLPTE YSRADAIFNT AHLGLLLRGL QTGKGEWLRA ALQDKLHQPY RQALIPGYDA
     VNTAAVAAGA YGMVISGAGP TLLALADVSH AAAVAAAMST AWREAGIKAV VRSLALDTHG
     AT
//