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Q3M9C9

- KHSE_ANAVT

UniProt

Q3M9C9 - KHSE_ANAVT

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Protein

Homoserine kinase

Gene
thrB, Ava_2794
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi92 – 10211ATP Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. homoserine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-2828-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinase (EC:2.7.1.39)
Short name:
HK
Short name:
HSK
Gene namesi
Name:thrB
Ordered Locus Names:Ava_2794
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Homoserine kinaseUniRule annotationPRO_1000049106Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_2794.

Structurei

3D structure databases

ProteinModelPortaliQ3M9C9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0083.
HOGENOMiHOG000247199.
KOiK00872.
OMAiHIANEGT.
OrthoDBiEOG6DG2WK.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3M9C9-1 [UniParc]FASTAAdd to Basket

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MSVVSSVTVK VPGTTANLGP GFDCIGAALT IYNQFQFTRL ETSELIIQAT    50
GAEAERVPTD ESNLLYQAFV KLYQYIDQTP PGVKVEIELG VPLARGLGSS 100
ATAIVGGLVA ANRLAGEPLS QAQVMELAIA IEGHPDNVVP ALVGGCRLAA 150
TGAMGWEICD VPWHGDIVPV LAIPDFELST SEARRVLPTE YSRADAIFNT 200
AHLGLLLRGL QTGKGEWLRA ALQDKLHQPY RQALIPGYDA VNTAAVAAGA 250
YGMVISGAGP TLLALADVSH AAAVAAAMST AWREAGIKAV VRSLALDTHG 300
AT 302
Length:302
Mass (Da):31,492
Last modified:October 25, 2005 - v1
Checksum:i1388FF5076BC99D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA22407.1.
RefSeqiWP_011319547.1. NC_007413.1.
YP_323302.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA22407; ABA22407; Ava_2794.
GeneIDi3681630.
KEGGiava:Ava_2794.
PATRICi35426501. VBIAnaVar43351_3795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA22407.1 .
RefSeqi WP_011319547.1. NC_007413.1.
YP_323302.1. NC_007413.1.

3D structure databases

ProteinModelPortali Q3M9C9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240292.Ava_2794.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA22407 ; ABA22407 ; Ava_2794 .
GeneIDi 3681630.
KEGGi ava:Ava_2794.
PATRICi 35426501. VBIAnaVar43351_3795.

Phylogenomic databases

eggNOGi COG0083.
HOGENOMi HOG000247199.
KOi K00872.
OMAi HIANEGT.
OrthoDBi EOG6DG2WK.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00064 .
BioCyci AVAR240292:GCY3-2828-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00384. Homoser_kinase.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000676. Homoser_kin. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00191. thrB. 1 hit.
PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiKHSE_ANAVT
AccessioniPrimary (citable) accession number: Q3M9C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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