Reviewed, UniProtKB/Swiss-Prot Q3M9C9 (KHSE_ANAVT)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Ava_2794

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Homoserine kinase HAMAP MF_00384		PRO_1000049106
Regions
	Nucleotide binding	92 – 102	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3M9C9-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 1388FF5076BC99D2	FASTA	302	31,492
	10 20 30 40 50 60 MSVVSSVTVK VPGTTANLGP GFDCIGAALT IYNQFQFTRL ETSELIIQAT GAEAERVPTD 70 80 90 100 110 120 ESNLLYQAFV KLYQYIDQTP PGVKVEIELG VPLARGLGSS ATAIVGGLVA ANRLAGEPLS 130 140 150 160 170 180 QAQVMELAIA IEGHPDNVVP ALVGGCRLAA TGAMGWEICD VPWHGDIVPV LAIPDFELST 190 200 210 220 230 240 SEARRVLPTE YSRADAIFNT AHLGLLLRGL QTGKGEWLRA ALQDKLHQPY RQALIPGYDA 250 260 270 280 290 300 VNTAAVAAGA YGMVISGAGP TLLALADVSH AAAVAAAMST AWREAGIKAV VRSLALDTHG AT

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000117 Genomic DNA. Translation: ABA22407.1.
RefSeq	YP_323302.1.
3D structure databases
HSSP	HSSP built from PDB template 1H72 based on UniProtKB Q58504.
SMR	Q3M9C9. Positions 6-289.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3M9C9.
Genome annotation databases
GeneID	3681630.
GenomeReviews	Gene locus Ava_2794 in contig CP000117_GR.
KEGG	ava:Ava_2794.
NMPDR	fig|240292.3.peg.1374.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0083.
HOGENOM	HBG646290.
OMA	FDCLGAA.
PhylomeDB	Q3M9C9.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_2794-MONOMER.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR000870. Homoserine_kin. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
TIGRFAMs	TIGR00191. thrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_ANAVT

Accession

Primary (citable) accession number: Q3M9C9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2005
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)