Reviewed,
UniProtKB/Swiss-Prot Q3M9C9 (KHSE_ANAVT)
Last modified
February 9, 2010.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homoserine kinase Short name=HSK Short name=HK EC=2.7.1.39 | ||||
| Gene names |
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| Organism | Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 240292 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena |
Protein attributes
| Sequence length | 302 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384 |
| Pathway | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384 |
| Subcellular location | Cytoplasm Potential HAMAP MF_00384. |
| Sequence similarities | Belongs to the GHMP kinase family. Homoserine kinase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Threonine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | phosphorylation Inferred from electronic annotation. Source: InterPro threonine biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 302 | 302 | Homoserine kinase HAMAP MF_00384 | PRO_1000049106 | |||||
Regions | |||||||||
| Nucleotide binding | 92 – 102 | 11 | ATP Potential | ||||||
Sequences
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References
| [1] | "Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000117 Genomic DNA. Translation: ABA22407.1. |
| RefSeq | YP_323302.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1H72 based on UniProtKB Q58504. |
| SMR | Q3M9C9. Positions 6-289. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3M9C9. |
Genome annotation databases | |
| GeneID | 3681630. |
| GenomeReviews | Gene locus Ava_2794 in contig CP000117_GR. |
| KEGG | ava:Ava_2794. |
| NMPDR | fig|240292.3.peg.1374. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0083. |
| HOGENOM | HBG646290. |
| OMA | FDCLGAA. |
| PhylomeDB | Q3M9C9. |
Enzyme and pathway databases | |
| BioCyc | AVAR240292:AVA_2794-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00384. Homoser_kinase. [Tree] |
| InterPro | IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR000870. Homoserine_kin. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view] |
| Gene3D | G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. |
| Pfam | PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000676. Homoser_kin. 1 hit. |
| PRINTS | PR00958. HOMSERKINASE. |
| TIGRFAMs | TIGR00191. thrB. 1 hit. |
| PROSITE | PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KHSE_ANAVT | ||||||||
| Accession | Primary (citable) accession number: Q3M9C9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


