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Q3M9C9 (KHSE_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homoserine kinase

Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:Ava_2794
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

homoserine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Homoserine kinase HAMAP-Rule MF_00384
PRO_1000049106

Regions

Nucleotide binding92 – 10211ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q3M9C9 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: 1388FF5076BC99D2

FASTA30231,492
        10         20         30         40         50         60 
MSVVSSVTVK VPGTTANLGP GFDCIGAALT IYNQFQFTRL ETSELIIQAT GAEAERVPTD 

        70         80         90        100        110        120 
ESNLLYQAFV KLYQYIDQTP PGVKVEIELG VPLARGLGSS ATAIVGGLVA ANRLAGEPLS 

       130        140        150        160        170        180 
QAQVMELAIA IEGHPDNVVP ALVGGCRLAA TGAMGWEICD VPWHGDIVPV LAIPDFELST 

       190        200        210        220        230        240 
SEARRVLPTE YSRADAIFNT AHLGLLLRGL QTGKGEWLRA ALQDKLHQPY RQALIPGYDA 

       250        260        270        280        290        300 
VNTAAVAAGA YGMVISGAGP TLLALADVSH AAAVAAAMST AWREAGIKAV VRSLALDTHG 


AT 

« Hide

References

[1]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000117 Genomic DNA. Translation: ABA22407.1.
RefSeqYP_323302.1. NC_007413.1.

3D structure databases

ProteinModelPortalQ3M9C9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING240292.Ava_2794.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA22407; ABA22407; Ava_2794.
GeneID3681630.
KEGGava:Ava_2794.
PATRIC35426501. VBIAnaVar43351_3795.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
HOGENOMHOG000247199.
KOK00872.
OMAHIANEGT.
OrthoDBEOG6DG2WK.

Enzyme and pathway databases

BioCycAVAR240292:GCY3-2828-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_ANAVT
AccessionPrimary (citable) accession number: Q3M9C9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways