ID   Q3M9C0_TRIV2            Unreviewed;      1805 AA.
AC   Q3M9C0;
DT   25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   OrderedLocusNames=Ava_2803 {ECO:0000313|EMBL:ABA22416.1};
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
OC   Trichormus.
OX   NCBI_TaxID=240292 {ECO:0000313|EMBL:ABA22416.1, ECO:0000313|Proteomes:UP000002533};
RN   [1] {ECO:0000313|Proteomes:UP000002533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937 {ECO:0000313|Proteomes:UP000002533};
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; CP000117; ABA22416.1; -; Genomic_DNA.
DR   STRING; 240292.Ava_2803; -.
DR   KEGG; ava:Ava_2803; -.
DR   eggNOG; COG0515; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   eggNOG; COG4191; Bacteria.
DR   HOGENOM; CLU_000445_34_2_3; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR   PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:ABA22416.1};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:ABA22416.1};
KW   Transferase {ECO:0000313|EMBL:ABA22416.1}.
FT   DOMAIN          7..272
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          1544..1801
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   COILED          1508..1535
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1805 AA;  202399 MW;  1FF27416AA647212 CRC64;
     MLNIPGYTIS EELYDGSRTL VYRAIRQADT LPVVIKLLKN PYPSFSELVQ FRNQYTIAKN
     LNYPGIIATH SLEPLHNGYQ LVMEDFGGIS VKDYFVHNHY VASLDKFLQI AIALCDILDI
     LYRQRIIHKD IKPANILINP ETTQVKLIDF SIASLLPRET QTLINPNVLE GTLGYISPEQ
     TGRMNRGIDH RTDFYSLGAT FYELLTGKLP FPSEDAMELV HCHLAKAPTL VHEINLTIPS
     VLSDIVNKLM AKNAEDRYQS ALGLKYDLEK CLVQLQETGK IESFPIAQRD VCDRFIIPDK
     LYGREAEVET LLQAFERVST GNTEMMLVAG FSGIGKTAVV NEVHKPIVRQ RGYFIKGKYD
     QFQRNIPFSA FVQAFRDLMG QLLTESDAQI QQWKSQILAA VGENGQVIIE VIPELAGIIG
     QQPPIIELSG TAAQNRFNLL FQKFVQVFKT QEHPLVMFLD DLQWADSASL NLMQLLMSES
     GGGYLLLIGA YRDNEVSDAH PLMFSLAEIR KAQATINTIT LAPLSQSSLN QLVADTLSCS
     SAIAQPLTQL VYQKTKGNPF FSTQFIKAIY EDGLITFNGD EGNWQCDIVG VKESSLSDDV
     VEFMALQLQK LPQTTQNILK FAACIGNKFD LGILAIIWEK SLTETATALW KALQEGLILP
     QSEVYKFYVD REIQDEVKGS QTVTYKFLHD RVQQAAYSLI PAEQKQYTHF QIGQLLLQGL
     SQGEQEERIF DIVNQLNMGL DVITSNEQKQ ELAHLNLKAG QKAKLSAAYQ AAYDYCTIGM
     SVLSPDAWQQ DYPLMYSLHR DASEAAYLCG KFDQAEALYA ETLTYAQAPL DQAIVYRIQM
     TQYQLQGRNA EAIAIQRQSL QMLGWTIPTQ PEMIQAGLDA EIATVQQFLE QHTIESILAA
     PKMVDPSIAE MLRILQILFY AAWLDGQSTL ALLALAKMTT LSLQYGNSDM SPFGYAGYGL
     IANGVFKDCA TAYEFGEMAV QLCEQFDNAD VRGMTNFIFA ADVHSWSRPI READTYYNNA
     YQYGMEAGNW LTVGFMMMQS GSDRLTYGKH LDDLYAIAQN HAAFLHQIKS LDNLDALTAG
     VLQPIRHLLG LTKTLFTFDD DDFSEAEYLQ KYANAPYHLS WLYSVKIRHA YLFDQKSTYS
     DLIPQLSMIE TTISSHAKVP SSVFYVALMH LALAETATEA SERQHHWQAL LPLETSLKRW
     LKACPENIRH KFLLIQAEKA RIKKQKTKAI ELYEQAISQA QANQYGYEEA LANELAAKFY
     LDWGKVKIAQ VYMQEACYGY ARWGAKAKAH HLEKTYPQLL KPILQQQRIN FNPLETITFR
     GATSSTHTTT TSSTNISEIL DFTSVLKGAQ AISGCIELDE LIANLTRIIL ENSGAKKSVL
     ILPLEETWQV KAITSVNQES SSHTNIQTIL SSQSIEDCQD IPPKIINYVK NTQKPLIIDN
     CQTDIPGVIG EYMLEHQPKS VLCTPIIHQG HLVGILYLEN ELTSEVFNSE HLQVVNLLSS
     QAAISLENAR LYQKAQQALQ DLQQAQLQIV QSEKMSALGN LVAGVAHEMN NPLGFIAASL
     MQAQPIIADI TEHLKLYQEN LPDKIEKIAD HAQEIDLEYI LEDLPKMIES MTMACERLKN
     ISTSLRTFSR ADRDYKVPFN IHEGIESTIL ILKHRLKANE QRPAIEVVTE YADSPMIECF
     PGQINQVFMN ILANAIDALD EANMGRSFAE IQANHNKIMI RTLLENQQVK ITIADNGKGM
     SEEVKAKIFD HLFTTKMVGK GTGLGLAIAQ SIVVEKHGGT LTVNSTLGEG TEFVISLPIL
     DESQN
//