ID   AROE_ANAVT              Reviewed;         289 AA.
AC   Q3M8H2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=Ava_3106;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000117; ABA22714.1; -; Genomic_DNA.
DR   RefSeq; YP_323609.1; -.
DR   GeneID; 3680852; -.
DR   GenomeReviews; CP000117_GR; Ava_3106.
DR   KEGG; ava:Ava_3106; -.
DR   NMPDR; fig|240292.3.peg.2535; -.
DR   HOGENOM; Q3M8H2; -.
DR   OMA; Q3M8H2; PQANLLV.
DR   BioCyc; AVAR240292:AVA_3106-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    289       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000021255.
FT   NP_BIND     131    135       NADP (By similarity).
FT   ACT_SITE     70     70       Proton acceptor (Potential).
SQ   SEQUENCE   289 AA;  31410 MW;  36AE4B36C538BE0A CRC64;
     MITGKTKLLG VIGHPVEHSL SPVMHNAAIA QLGLDYVYLP FPIAPDNLEA AIALLATIGV
     VGFSVTIPHK QAIIPLLAEI SPVAQAIGAV NTVTRQNNQW VGTNTDIEGF IAPLQTTYKR
     DWSQQIAVIL GNGGAARAVV AGCYQLGFAE IHVVGRNVQR LEEFRHSWDN SPIAENLQVH
     TWDYLAKLVP QANLLVNTTP IGMYPQVDES PLSTEELANL QTGAIAYDLI YIPKPTQFLQ
     KAQQQGAIAI DGLEMLVQQG VAALKIWLQQ DDIPVDVMRQ ALQKHLGLV
//