Reviewed, UniProtKB/Swiss-Prot Q3M8H2 (AROE_ANAVT)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Ava_3106

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021255
Regions
	Nucleotide binding	131 – 135	5	NADP By similarity
Sites
	Active site	70	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3M8H2-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 36AE4B36C538BE0A	FASTA	289	31,410
	10 20 30 40 50 60 MITGKTKLLG VIGHPVEHSL SPVMHNAAIA QLGLDYVYLP FPIAPDNLEA AIALLATIGV 70 80 90 100 110 120 VGFSVTIPHK QAIIPLLAEI SPVAQAIGAV NTVTRQNNQW VGTNTDIEGF IAPLQTTYKR 130 140 150 160 170 180 DWSQQIAVIL GNGGAARAVV AGCYQLGFAE IHVVGRNVQR LEEFRHSWDN SPIAENLQVH 190 200 210 220 230 240 TWDYLAKLVP QANLLVNTTP IGMYPQVDES PLSTEELANL QTGAIAYDLI YIPKPTQFLQ 250 260 270 280 KAQQQGAIAI DGLEMLVQQG VAALKIWLQQ DDIPVDVMRQ ALQKHLGLV

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA22714.1.
RefSeq	YP_323609.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3680852.
GenomeReviews	Gene locus Ava_3106 in contig CP000117_GR.
KEGG	ava:Ava_3106.
NMPDR	fig|240292.3.peg.2535.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3M8H2.
OMA	Q3M8H2. PQANLLV.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_3106-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_ANAVT

Accession

Primary (citable) accession number: Q3M8H2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)