ID   TPIS_ANAVT              Reviewed;         241 AA.
AC   Q3M7Y8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Triosephosphate isomerase;
DE            Short=TIM;
DE            EC=5.3.1.1;
DE   AltName: Full=Triose-phosphate isomerase;
GN   Name=tpiA; OrderedLocusNames=Ava_3290;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate from glycerone phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR   EMBL; CP000117; ABA22898.1; -; Genomic_DNA.
DR   RefSeq; YP_323793.1; -.
DR   GeneID; 3680321; -.
DR   GenomeReviews; CP000117_GR; Ava_3290.
DR   KEGG; ava:Ava_3290; -.
DR   NMPDR; fig|240292.3.peg.2096; -.
DR   HOGENOM; Q3M7Y8; -.
DR   OMA; Q3M7Y8; IGAQDCH.
DR   BioCyc; AVAR240292:AVA_3290-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:HAMAP.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR   HAMAP; MF_00147; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000652; Triosephosphate_isomerase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR21139; Triophos_ismrse; 1.
DR   Pfam; PF00121; TIM; 1.
DR   ProDom; PD001005; Triophos_ismrse; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00171; TIM_1; 1.
DR   PROSITE; PS51440; TIM_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase;
KW   Pentose shunt.
FT   CHAIN         1    241       Triosephosphate isomerase.
FT                                /FTId=PRO_0000307423.
FT   ACT_SITE     96     96       Electrophile (By similarity).
FT   ACT_SITE    165    165       Proton acceptor (By similarity).
FT   BINDING       9      9       Substrate (By similarity).
FT   BINDING      11     11       Substrate (By similarity).
SQ   SEQUENCE   241 AA;  26577 MW;  10BDF34603CF661D CRC64;
     MRKIVIAGNW KMFKTQAESQ EFLKEFLPAL EETPQEREVL LCVPFTDLAI LSQSLHGSLV
     QLGAQNVHWA ENGAYTGEIS GPMLTEIGVR YVIVGHSERR QFFGETDETV NLRLQAAQKY
     GLTPILCVGE TKQQRDSGET ESLIVSQLDK DLINVDQTNL VIAYEPIWAI GTGDTCETTE
     ANRVIGLIRS QLKNPDVPIQ YGGSVKPNNI DEIMAQPEID GVLVGGASLE AASFARIVNY
     Q
//