ID   HIS4_ANAVT              Reviewed;         257 AA.
AC   Q3M7Q7;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE            EC=5.3.1.16;
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN   Name=hisA; OrderedLocusNames=Ava_3372;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-
CC       ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-
CC       phosphoribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the hisA/hisF family.
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DR   EMBL; CP000117; ABA22979.1; -; Genomic_DNA.
DR   RefSeq; YP_323874.1; -.
DR   GeneID; 3680072; -.
DR   GenomeReviews; CP000117_GR; Ava_3372.
DR   KEGG; ava:Ava_3372; -.
DR   NMPDR; fig|240292.3.peg.2319; -.
DR   HOGENOM; Q3M7Q7; -.
DR   OMA; Q3M7Q7; VATRGWL.
DR   BioCyc; AVAR240292:AVA_3372-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylam...; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01014; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006063; His4.
DR   InterPro; IPR006062; His_biosynth.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00977; His_biosynth; 1.
DR   TIGRFAMs; TIGR00007; His4; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Isomerase.
FT   CHAIN         1    257       1-(5-phosphoribosyl)-5-[(5-
FT                                phosphoribosylamino)methylideneamino]
FT                                imidazole-4-carboxamide isomerase.
FT                                /FTId=PRO_0000229040.
FT   ACT_SITE      8      8       Proton acceptor (By similarity).
FT   ACT_SITE    129    129       Proton donor (By similarity).
SQ   SEQUENCE   257 AA;  27244 MW;  8D8B2443C7F089A5 CRC64;
     MDVIPAIDLL EGRCVRLYQG DYDRSQVFSE NPVDVAKQWV DEGATRLHIV DLDGAKAGKV
     VNLGAIEAIA QAISIPIEIG GGLRDRSSVE QVFNLGVQWA ILGTVAVEQP QLVQELCQQY
     PGQIIIGIDA RNGLVATRGW LETSEVLATQ LAVQMQEMGA AAIIYTDIHR DGTLAGPNLD
     ALRELAAAIS IPVIASGGVS SVTDLLSLLA LEPQGVTGVI VGRALYTGDI NLKEALQAIG
     PGRIQDIPPN LDFSSFA
//