ID   Q3M794_TRIV2            Unreviewed;      1804 AA.
AC   Q3M794;
DT   25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 123.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   OrderedLocusNames=Ava_3535 {ECO:0000313|EMBL:ABA23142.1};
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
OC   Trichormus.
OX   NCBI_TaxID=240292 {ECO:0000313|EMBL:ABA23142.1, ECO:0000313|Proteomes:UP000002533};
RN   [1] {ECO:0000313|Proteomes:UP000002533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937 {ECO:0000313|Proteomes:UP000002533};
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; CP000117; ABA23142.1; -; Genomic_DNA.
DR   STRING; 240292.Ava_3535; -.
DR   KEGG; ava:Ava_3535; -.
DR   eggNOG; COG0515; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   eggNOG; COG4191; Bacteria.
DR   HOGENOM; CLU_000445_34_2_3; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR   PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:ABA23142.1};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:ABA23142.1};
KW   Transferase {ECO:0000313|EMBL:ABA23142.1}.
FT   DOMAIN          14..273
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          1546..1803
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   COILED          1510..1537
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1804 AA;  202826 MW;  266494E6E703A642 CRC64;
     MATQQYSNPI ITGYQISSQL YAGSKTRVYR AIREQDQLPV VIKVLASDYP NFQELLQFRN
     QYTISKNLNV TGIIRPLSLE TYGNGYILVM EDTGGIALRE YIKTAPLPLV EFLAIAIQIT
     SILQELHLNR VIHKDIKPAN ILIHPQTKQV HLIDFSIASL LPKETQEIRS PNVLEGTLAY
     ISPEQTGRMN RGIDYRSDFY SLGVTLYELL MGELPFSSDD PMELVYCHIA KTPIALGHQQ
     HIPLVLSDII MKLMAKNAED RYQSALGLKH DLETCLYQCK NNGKITAFEI GKRDMCDRFL
     IPEKLYGRET EVKVLLQAFE RVTKGKSEMM LVAGFSGIGK TAVVNEVHKP ITRQQGYFIK
     GKFDQFNRNL PLSAFVQALR DLMGQLLSES DSQLSKWRTK ILDTVGNNGQ VLIEVIPELE
     IIIGKQHPAP ELSGIAAQNR FNLLFQKFIA IFSTPKHPLV MFLDDLQWAD TGSLQLIKLL
     MEDQSYLLLL GAYRDNEVHT AHPLILTVEE LKKAGKTVNK ITLASLTLCD TNHLVADTLH
     CQAERSHPLT ELIERKTKGN PFFITQFLKA LHEDQLITFN RHQGYWECDI TQINELSLTD
     DVVKFMAQKL QKFPSKTQDV LKLAACIGNS FDLNTLAIVL EKSAADTADA LWKALQEGLI
     LPQSEVYKFY LDHDRQDAHV NNSQNVEYRF LHDRVQQAAY SLIPQDQKQA THYQIGQLLL
     KQISPVAREE RIFELVNQLN YGVALITQQT ERDELAQLNL TACRKARSAT AYQAAHEYIT
     VGLLLLGEKA WQHQYEITLH LHEFAAEVAS LRGDFAQMEQ FINIVTAQAH TLIEQVNVYR
     IRIQAYISQN KFAEAIAIAQ KILQQLGVTF AEATTPAVIQ QEIQEIRELI GDRAIADLVH
     LPIITDEEKV AIVQIASSIM TVAYLSGSPL FPLITLLLVK ISIQYGNTPA TGYIYSTYGV
     LLCNVLQDVD TATEFGQLAL QIVSKVDAKA TQPQVLLVLA LYILQRKSHV QEILPLLQKG
     YAIALEVGNL EFAGHHAHNF CSHSFWCGQH LATLQEDARA YSNELEQLNQ ITTANYVRIY
     WQSTLNLLGF AVHPTILSGE ALQEQEFIPL LIAANDGYGL YIFYLYKLML CYLFGEIETA
     KSITIKIKDH LMAAAGLFCE PIFYLYDSLI ALAQLRQNSE EVSATLQYVA ENQAKLQRWA
     QYAPMNHQHK LDLVAAERYR VLGEKTSAIE YYDHAISGAK KSQYIQEEAL SNELAAKFYL
     DWGKDKVAQI YMQEAYYCYA RWGAKAKIDN LEKLYPQLLK PILQRRQLNL NPLETIAPIN
     RNTIAVPTDT AGTSSTSISD ILDFTSVLKA AQAISSTIEL EELIVNLTKI ILEISGAKKI
     VLILPQDNAW YVRAITFISY ENKPEGKIQN ILLLQPIDTC KHIPGTIINY VKNTLETLVI
     DNYQIDIPGL IDQYLLKHQP KSVLCQPIIK QSNLLGILYL ENQITSGVFT LERLQVINLL
     SSQAAISLEN ACLYQKAQQA LQDLQAAQLQ IIQSEKMSAL GNLVAGVAHE MNNPLGFITA
     TLKQAKPTIA DIAEHLRLYQ ANFPNKSAEI INHAEEIDLD YSLEDLPKMI DAMVMASDRL
     KNISTSLRTF SRADTDHKVS FNVHEGIDST ILILKHRLKA NEQRPAIEVI TDYGNLPQIE
     CFPGQLNQVF MNILANAIDA LEATNKGQTL EEIKAHPHQI TITTTVNNDQ VKIIIADNGI
     GMDEQVKQKI FDHLFTTKAV GKGTGLGLAI ARQIVVEKHN GSLFVNSQLG AGTEFVITLP
     IITR
//