Reviewed, UniProtKB/Swiss-Prot Q3M6S3 (G6PI_ANAVT)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Ava_3708

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 528	528	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000230911
Sites
	Active site	322	1	Proton donor By similarity
	Active site	351	1	By similarity
	Active site	455	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3M6S3-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 2A6A1329F27AFFA0	FASTA	528	57,743
	10 20 30 40 50 60 MDAKALWQRY QEWLYFHEGL GLYLDVSRMR FDDAFVKSLL PKFDKAFADM AELEKGAIAN 70 80 90 100 110 120 PDENRMVGHY WLRNPDLAPT PEIAQEIVQT LEQIEAFAEK IQTGAIHPPK ANRFTDIISI 130 140 150 160 170 180 GIGGSALGPQ FVAEALAPEF PPLKIHFIDN TDPAGIDKIL THLRNNLAST LVLVISKSGG 190 200 210 220 230 240 TPEPRNGMIE VKKAYAGQNL DFAQYAVAIT STGSNLDKVA QAEGWLATFP MYDWVGGRTS 250 260 270 280 290 300 EMSSVGLVPA ALQGIDVRAM LEGAKEMDDA TRVPEVKNNP AALLALSWYY SGNGKGEKDM 310 320 330 340 350 360 VVLPYKDSLL LFSRYLQQLV MESLGKEKDL DGKTVYQGIA VYGNKGSTDQ HAYVQQLREG 370 380 390 400 410 420 VPNFFATLIE VLEDRNGASP EIDPGVTSGD YLSGFLLGTR QALYENQRDS ITVTIPQVNA 430 440 450 460 470 480 RTVGALIALY ERTVGLYASL VNINAYHQPG VEAGKKAAAV ILDLQTKVVG LLQKEKTALS 490 500 510 520 LEQIAEKIGA ADQVEAIYKI LRHLQANQRG VVFQGNLGQP SSLKVSIS

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA23313.1.
RefSeq	YP_324208.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3678794.
GenomeReviews	Gene locus Ava_3708 in contig CP000117_GR.
KEGG	ava:Ava_3708.
NMPDR	fig|240292.3.peg.4861.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3M6S3.
OMA	Q3M6S3. PYSNDLA.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_3708-MON.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ANAVT

Accession

Primary (citable) accession number: Q3M6S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)