ID   PUR9_ANAVT              Reviewed;         506 AA.
AC   Q3M6G3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Bifunctional purine biosynthesis protein purH;
DE   Includes:
DE     RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase;
DE              EC=2.1.2.3;
DE     AltName: Full=AICAR transformylase;
DE   Includes:
DE     RecName: Full=IMP cyclohydrolase;
DE              EC=3.5.4.10;
DE     AltName: Full=Inosinicase;
DE     AltName: Full=IMP synthetase;
DE     AltName: Full=ATIC;
GN   Name=purH; OrderedLocusNames=Ava_3818;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-
CC       formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
CC   -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl
CC       THF route): step 1/1.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamide: step 1/1.
CC   -!- DOMAIN: The IMP cyclohydrolase activity resides in the N-terminal
CC       region (By similarity).
CC   -!- SIMILARITY: Belongs to the purH family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000117; ABA23423.1; -; Genomic_DNA.
DR   RefSeq; YP_324318.1; -.
DR   GeneID; 3678750; -.
DR   GenomeReviews; CP000117_GR; Ava_3818.
DR   KEGG; ava:Ava_3818; -.
DR   NMPDR; fig|240292.3.peg.4110; -.
DR   HOGENOM; Q3M6G3; -.
DR   OMA; Q3M6G3; VVKHVKS.
DR   BioCyc; AVAR240292:AVA_3818-MON; -.
DR   GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:HAMAP.
DR   GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide for...; IEA:HAMAP.
DR   GO; GO:0006188; P:IMP biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00139; -; 1.
DR   InterPro; IPR002695; AICARFT_IMPCHas.
DR   InterPro; IPR013982; AICARFT_IMPCHas_formly.
DR   InterPro; IPR011607; MGS.
DR   PANTHER; PTHR11692; AICARFT_IMPCHas; 1.
DR   Pfam; PF01808; AICARFT_IMPCHas; 1.
DR   Pfam; PF02142; MGS; 1.
DR   PIRSF; PIRSF000414; AICARFT_IMPCHas; 1.
DR   SMART; SM00798; AICARFT_IMPCHas; 1.
DR   TIGRFAMs; TIGR00355; purH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Multifunctional enzyme;
KW   Purine biosynthesis; Transferase.
FT   CHAIN         1    506       Bifunctional purine biosynthesis protein
FT                                purH.
FT                                /FTId=PRO_1000018836.
SQ   SEQUENCE   506 AA;  54099 MW;  6B15CD33EA1B879F CRC64;
     MARLALLSVS NKTGLIDLAR RLVEEFEFDL ISSGGTAQAL KDAGLPVTKV ADYTGSPEIL
     GGRVKTLHPR IHGGILARRD VPSDLTDLEN NQIRPIDLVV VNLYPFEETI AKPGVTLAEA
     VEQIDIGGPA MLRASSKNFA HLTVLCDPAQ YDEYLQELRQ NNGVASLEFR QKAALKGFLH
     TASYDSAIAS YLSGTQQHTL NGTELQSLRY GENPHQPAAW YQTGTTPTGW TAAKKLQGKE
     LSYNNLVDLE AARRIIAEFT DTPAATIIKH TNPCGTALAD TIVEAYQKAF NADATSAFGG
     IVALNRPIDA ATASELTKTF LECVVAPDCD AEAQKILAKK SNVRVLTLAD LSTGPKTLVK
     QIAGGFLVQA ADDIAADTIQ WQVVTERQPT ADELAELLFA WKVCKHVKSN AIVVTSDRTT
     LGVGAGQMNR IGSTKIALEQ AGDKAKGAIL ASDGFFPFDD TVRTAAAAGI SAIVQPGGSL
     RDQDSVKAAN ELGLLMVLTG VRHFLH
//