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Q3M5D3

- HISX2_ANAVT

UniProt

Q3M5D3 - HISX2_ANAVT

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Protein

Histidinol dehydrogenase 2

Gene
hisD2, Ava_4204
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NAD By similarity
Binding sitei192 – 1921NAD By similarity
Binding sitei215 – 2151NAD By similarity
Binding sitei238 – 2381Substrate By similarity
Metal bindingi260 – 2601Zinc By similarity
Binding sitei260 – 2601Substrate By similarity
Metal bindingi263 – 2631Zinc By similarity
Binding sitei263 – 2631Substrate By similarity
Active sitei328 – 3281Proton acceptor By similarity
Active sitei329 – 3291Proton acceptor By similarity
Binding sitei329 – 3291Substrate By similarity
Metal bindingi362 – 3621Zinc By similarity
Binding sitei362 – 3621Substrate By similarity
Binding sitei416 – 4161Substrate By similarity
Metal bindingi421 – 4211Zinc By similarity
Binding sitei421 – 4211Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-4253-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:Ava_4204
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histidinol dehydrogenase 2UniRule annotationPRO_0000229849Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_4204.

Structurei

3D structure databases

ProteinModelPortaliQ3M5D3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiFQEITRE.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3M5D3-1 [UniParc]FASTAAdd to Basket

« Hide

MLRIITQQAD VKAELQRICD RTHDEQVLHK EATVREVLQA VKRQGDKAVL    50
HYTDEFDNQI LKAEELRVTG SELDAAYQQV SKELLEAIQL ASRQIEAFHR 100
QRVPKSWVHF GDDDIVLGKR YTPVDRAGLY VPGGRAAYVS TVLMNAIPAK 150
VAGVPRIVMA TPPGAQKAIN PAVLVAAQEV GVQEIYRVGG AQAIAALAYG 200
TETIPKVDVI TGPGNIYVTL AKKLVYGTVG IDSLAGPSEV LIIADEGANP 250
VHVATDMLAQ AEHDPMAAAI LFTTDPALAK NVQVAVERQL VDHPRRIDTE 300
KAIAHYGLIV LVESLDAAAE LSNEFAPEHL ELEVKDPWAV LPNIRHAGAI 350
FLGYSTPEAV GDYLAGPNHT LPTSGAARYA SALSVETFLK HSSIIQYSQT 400
ALNKVAGAID ALATAEGLPS HADSVKRRIQ QDE 433
Length:433
Mass (Da):46,701
Last modified:October 25, 2005 - v1
Checksum:i5C294698068A3ABA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA23803.1.
RefSeqiWP_011320885.1. NC_007413.1.
YP_324698.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA23803; ABA23803; Ava_4204.
GeneIDi3680948.
KEGGiava:Ava_4204.
PATRICi35429761. VBIAnaVar43351_5410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000117 Genomic DNA. Translation: ABA23803.1 .
RefSeqi WP_011320885.1. NC_007413.1.
YP_324698.1. NC_007413.1.

3D structure databases

ProteinModelPortali Q3M5D3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240292.Ava_4204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA23803 ; ABA23803 ; Ava_4204 .
GeneIDi 3680948.
KEGGi ava:Ava_4204.
PATRICi 35429761. VBIAnaVar43351_5410.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi FQEITRE.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci AVAR240292:GCY3-4253-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiHISX2_ANAVT
AccessioniPrimary (citable) accession number: Q3M5D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2005
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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