Reviewed, UniProtKB/Swiss-Prot Q3M4V2 (AROB_ANAVT)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Ava_4386

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000231061

Sequences

	Sequence		Length	Mass (Da)
	Q3M4V2-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: FD37679FEEAA18D2	FASTA	363	39,290
	10 20 30 40 50 60 MTSVINVNLP TQSYEIAIAP ASLDQIGQSL AGLKLGKKVL LVSNPTIFKH FGKVAVDSLE 70 80 90 100 110 120 AAGFQVASYC LPAGERYKTL NSIQKLYDIA LENRLERSST MVALGGGVIG DMTGFAAATW 130 140 150 160 170 180 LRGINVVQVP TTLLAMVDSA IGGKTGVNHP HGKNLIGAFH QPRFVLIDPQ VLKTLPVREF 190 200 210 220 230 240 RAGMAEVIKY GVIWDAELFN QLEQSKRLDQ LRYIKPELMD AILTRSCQAK ADVVGKDEKE 250 260 270 280 290 300 GGLRAILNYG HTVGHAVESL TNYRLLKHGE AVGIGMVAAG QIAVNLGLWQ QADADRQNAL 310 320 330 340 350 360 IEKAGLPTKL PAGLDIEGII EALQLDKKVK DGKVRFVLPT QIGVVTVTDE VTSDHIRQVL QQM

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA23984.1.
RefSeq	YP_324879.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3M4V2.
Genome annotation databases
GeneID	3680572.
GenomeReviews	Gene locus Ava_4386 in contig CP000117_GR.
KEGG	ava:Ava_4386.
NMPDR	fig|240292.3.peg.4765.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3M4V2.
OMA	NRLERSS.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_4386-MON.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ANAVT

Accession

Primary (citable) accession number: Q3M4V2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 25, 2005
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)