Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Anthranilate 1; via carbonyl oxygenUniRule annotation
Binding sitei103 – 1031Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei111 – 1111PhosphoribosylpyrophosphateUniRule annotation
Metal bindingi115 – 1151Magnesium 1UniRule annotation
Binding sitei134 – 1341Anthranilate 1UniRule annotation
Binding sitei143 – 1431Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei189 – 1891Anthranilate 2UniRule annotation
Metal bindingi248 – 2481Magnesium 2UniRule annotation
Metal bindingi249 – 2491Magnesium 1UniRule annotation
Metal bindingi249 – 2491Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-4464-MONOMER.
UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Ava_4408
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
Proteomesi
  • UP000002533 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Anthranilate phosphoribosyltransferasePRO_1000042989Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi240292.Ava_4408.

Structurei

3D structure databases

ProteinModelPortaliQ3M4T0.
SMRiQ3M4T0. Positions 13-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni113 – 1164Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni131 – 1399Phosphoribosylpyrophosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RNB. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiHSGQAYQ.
OrthoDBiEOG6D5G6B.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3M4T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSPIPTQE SSTSWYLLLQ QLIDGESLSR SQAAELMQGW LSEAVPPELS
60 70 80 90 100
GAILTALNFK GVSADELTGM AEVLQSQSKL GSGENSSQLP ITNYQFPIID
110 120 130 140 150
TCGTGGDGSS TFNISTAVAF VAAAYGVPVA KHGNRSASSL TGSADVLEAL
160 170 180 190 200
GVNLGASSEK VQAALQEVGI TFLFAPGWHP ALKAVATLRR TLRIRTVFNL
210 220 230 240 250
LGPLVNPLRP TGQVVGLFTP KLLTTVAQAL DNLGKQKAIV LHGRERLDEA
260 270 280 290 300
GLGDLTDLAV LSDGKLQLTT INPQEVGVTP APIGALRGGD VQENAEILKA
310 320 330 340 350
VLQGQGTQAQ QDAVALNAAL ALQVAGAVPL LDHAKGVSVA KEILQTGTAW
360
AKLEQLVHFL KS
Length:362
Mass (Da):37,708
Last modified:October 25, 2005 - v1
Checksum:i3A42BBB7518B0E64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA24006.1.

Genome annotation databases

EnsemblBacteriaiABA24006; ABA24006; Ava_4408.
KEGGiava:Ava_4408.
PATRICi35430225. VBIAnaVar43351_5635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA. Translation: ABA24006.1.

3D structure databases

ProteinModelPortaliQ3M4T0.
SMRiQ3M4T0. Positions 13-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi240292.Ava_4408.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA24006; ABA24006; Ava_4408.
KEGGiava:Ava_4408.
PATRICi35430225. VBIAnaVar43351_5635.

Phylogenomic databases

eggNOGiENOG4107RNB. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiHSGQAYQ.
OrthoDBiEOG6D5G6B.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.
BioCyciAVAR240292:GCY3-4464-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiTRPD_ANAVT
AccessioniPrimary (citable) accession number: Q3M4T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2005
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.