ID   Q3M4R3_TRIV2            Unreviewed;       880 AA.
AC   Q3M4R3;
DT   25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase with FHA and GAF sensor {ECO:0000313|EMBL:ABA24023.1};
GN   OrderedLocusNames=Ava_4425 {ECO:0000313|EMBL:ABA24023.1};
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
OC   Trichormus.
OX   NCBI_TaxID=240292 {ECO:0000313|EMBL:ABA24023.1, ECO:0000313|Proteomes:UP000002533};
RN   [1] {ECO:0000313|Proteomes:UP000002533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937 {ECO:0000313|Proteomes:UP000002533};
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
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DR   EMBL; CP000117; ABA24023.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3M4R3; -.
DR   STRING; 240292.Ava_4425; -.
DR   KEGG; ava:Ava_4425; -.
DR   eggNOG; COG1716; Bacteria.
DR   eggNOG; COG2203; Bacteria.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_70_20_3; -.
DR   Proteomes; UP000002533; Chromosome.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
FT   DOMAIN          31..91
FT                   /note="FHA"
FT                   /evidence="ECO:0000259|PROSITE:PS50006"
FT   DOMAIN          479..612
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          621..875
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   880 AA;  98949 MW;  B3ECEB57B8898640 CRC64;
     MPGNEWEKIR HILVVQDLQG QRTIPLQEAT YSIGRHTSNA IVLHSRSVSR QHAILLRVTL
     PETDQCSFRI IDGNFKGQGS TNGLLVNGTR CFSHNLRHGD VINFGSHQAQ AKYYAISNIS
     EKAFFASADV EDLSTFLSEL SQPVNPFQTL VVDPEFEGAS ETALARLASF PELIPNPIIE
     TDLEGRVTYI NPAASVKFPD LRELGKRHPI LKDILNVAEN PKINPFVREV TVGHAVYEQS
     VHNLPESDLI RTYIIRDITE QKQAEAELHQ RDRLLQAVAE AANWLVVEMN YDTAIEKALA
     VVGEAAQADR AYLFKNHPHP VTGKTAVSLQ FEWYCSGLQP SIQYWQNQLY QSAELSRWYS
     ILSSGKSINE LRRKLPIVER ELLERQGIQS LLLVPLRLED QFWGYLGLAD CTQERYWSRH
     EESTLLTMAA SISGAWQRQQ VEEKIRYQAL HDLLTGLPNR LLFNELLAKA LANASRSQQS
     LAVMFLDLDR FKVINDTLGH SLGDRLLKSV AQRLCDCLRS GDTVSRWGGD EFTILLPHIS
     YIEEVTQAAY RILKALEEVF HLDGHELYVS ASLGIALLDH HSPDAEALIK HADAALYHAK
     DEGRNNYQFY TTSLSGKTPE LLTLEKSLRY ALEKQELTVY YQPRVNILTG QITGMEALLR
     WQHPEMGIVA PSIFIPIAEE TGLIIPIGEW VLRTACMQNR AWQEAGLPPL QMAVNLSPKQ
     FRQPNLLEIV SAILAETSLA PEFLELEITE STAIEDIDFT RSVLENLQQM GVDIAIDDFG
     TGHSSLSRLQ LLPLHNLKID GSFIKALTTD SKVAHIVKAI VTLGRSLGLR LTAEGVEKQE
     ELDFLKSINC QDVQGFLFYK PLSAEKATEI LQSERKHAAL
//